Understanding the genetic regulation of IgE production

Blood Reviews
John AltinAdrian Liston

Abstract

Immunoglobulin E (IgE) is a key mediator of anti-parasitic and anti-tumour immunity. However it is also a critical component of atopic and autoimmune diseases, and elevated serum IgE levels are a common indicator of immune dysregulation. In this review we survey the literature on genetic associations of elevated IgE in humans and mice. We find that defects in a limited number of pathways explain the majority of gene associations with IgE. Commonly, elevated IgE is associated with defects in Th bias and B cell class switching, severe T cell tolerance defects and defects in immunity at the host-environment interface. These genetic data demonstrate the mechanisms of control over IgE production and the manner in which they can be circumvented.

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Citations

May 9, 2012·Nature Medicine·Stephen T Holgate
May 23, 2013·Orphanet Journal of Rare Diseases·Dina Danso-AbeamAdrian Liston
May 27, 2014·Indian Dermatology Online Journal·Ola Ahmed BakryHanan Mostafa
Aug 23, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D P Potaczek, M Kabesch
Oct 24, 2012·Vaccine·Laurel J GershwinMatt X Shao
Aug 27, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nan YangXiu-Min Li
Sep 27, 2016·Kidney Research and Clinical Practice·Ji-Hoon LeeChun Gyoo Ihm
Jul 22, 2014·Korean journal of pediatrics·Hyeong Yun KimMan Yong Han
Nov 8, 2018·Therapeutic Advances in Respiratory Disease·Corrado PelaiaGirolamo Pelaia
Nov 30, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisa A NigroLuca Vangelista
Nov 14, 2019·Immune Network·Ferdaus Mohd Altaf HossainSeong Kug Eo

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