Understanding the HIV Epidemic Among MSM in Baltimore: A Modeling Study Estimating the Impact of Past HIV Interventions and Who Acquired and Contributed to Infections.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Romain SilholKate M Mitchell

Abstract

Men who have sex with men (MSM) in the United States are disproportionately affected by HIV. We estimated the impact of past interventions and contribution of different population groups to incident MSM HIV infections. Baltimore, US. We used a deterministic model, parameterized and calibrated to demographic and epidemic Baltimore MSM data, to estimate the fraction of HIV infections among MSM averted by condoms and antiretroviral therapy (ART) over 1984-2017 and the fraction of infections acquired and transmission contributed by MSM from different demographic groups and disease and care continuum stages over 10-year periods from 1988 to 2017, using population attributable fractions. Condom use and ART averted 19% (95% uncertainty interval: 14%-25%) and 23% (15%-31%) of HIV infections that would have occurred since 1984 and 1996, respectively. Over 2008-2017, 46% (41%-52%) of incident infections were acquired by and 35% (27%-49%) of transmissions contributed by MSM aged 18-24 years (who constitute 27% of all MSM, 19% of HIV+ MSM). MSM with undiagnosed HIV infection, those with diagnosed infection but not in care, and those on ART contributed to 41% (31%-54%), 46% (25%-56%), and 14% (7%-28%) of transmissions, respectively. Condoms...Continue Reading

References

Mar 18, 2004·American Journal of Preventive Medicine·Alexander K RoweW Dana Flanders
May 4, 2006·American Journal of Public Health·Gregorio A MillettRon Stall
Feb 8, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Danielle GermanDavid R Holtgrave
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Sep 21, 2011·European Journal of Epidemiology·Narat PunyacharoensinRichard Guy White
Jul 24, 2012·Lancet·Chris BeyrerRon Brookmeyer
Sep 29, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard D MooreJohn G Bartlett
Dec 5, 2012·PloS One·Steven M GoodreauSusan P Buchbinder
Dec 18, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Peter RebeiroUNKNOWN North American AIDS Cohort Collaboration on Research and Design
Aug 8, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A MocroftUNKNOWN Opportunistic Infections Working Group on behalf of the Collaboration of Observational HIV Epidemiological Research Europe (
Nov 7, 2013·PloS One·Cyprian WejnertUNKNOWN Gabriela Paz-Bailey for the NHBS Study Group
Feb 5, 2014·Journal of the International Association of Providers of AIDS Care·Ellen M TedaldiUNKNOWN HOPS Investigators
Dec 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dawn K SmithCharles E Rose
Oct 9, 2015·MMWR. Morbidity and Mortality Weekly Report·Kristen Mahle GrayH Irene Hall
Jun 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brooke E HootsUNKNOWN National HIV Behavioral Surveillance Study Group
Jun 17, 2016·AIDS and Behavior·Lina M NerlanderGabriela Paz-Bailey
Jul 13, 2016·JAMA : the Journal of the American Medical Association·Alison J RodgerUNKNOWN PARTNER Study Group
Jun 13, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Danielle GermanUNKNOWN Mid-Atlantic CFAR Consortium
Mar 22, 2019·MMWR. Morbidity and Mortality Weekly Report·Zihao LiH Irene Hall
Nov 23, 2019·The Lancet Infectious Diseases·Sharmistha Mishra, Stefan D Baral

❮ Previous
Next ❯

Citations

Nov 26, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Romain SilholMarie-Claude Boily

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.