Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

Toxicology and Applied Pharmacology
A N Ilinskaya, Marina A Dobrovolskaia

Abstract

Nanoparticle immunogenicity and antigenicity have been under investigation for many years. During the past decade, significant progress has been made in understanding what makes a nanoparticle immunogenic, how immune cells respond to nanoparticles, what consequences of nanoparticle-specific antibody formation exist and how they challenge the application of nanoparticles for drug delivery. Moreover, it has been recognized that accidental contamination of therapeutic protein formulations with nanosized particulate materials may contribute to the immunogenicity of this type of biotechnology products. While the immunological properties of engineered nanomaterials and their application as vaccine carriers and adjuvants have been given substantial consideration in the current literature, little attention has been paid to nanoparticle immuno- and antigenicity. To fill in this gap, we herein provide an overview of this subject to highlight the current state of the field, review past and present research, and discuss future research directions.

References

Dec 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·P D NguyenB M Fung
Jun 1, 1986·Chemistry and Physics of Lipids·C R Alving
Apr 1, 1984·Biochemical Society Transactions·C R Alving
Nov 26, 1993·Science·M F BachmannR M Zinkernagel
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C F BarbasR A Lerner
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·B X ChenB F Erlanger
Jul 5, 2002·Seminars in Thrombosis and Hemostasis·Jens KlingeEvgueni L Saenko
Jun 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Gregory J R Charrois, Theresa M Allen
Jan 17, 2004·Pharmaceutical Research·Suzanne HermelingWim Jiskoot
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Jun 24, 2004·Pharmaceutical Research·Suzanne HermelingWim Jiskoot
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Nov 9, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Adam JudgeIan Maclachlan
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Mar 7, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Oct 3, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Oct 19, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Nov 18, 2006·Journal of Thrombosis and Thrombolysis·Adinarayana KunamneniPoluri Ellaiah
Nov 30, 2006·The Journal of Pharmacy and Pharmacology·Hrushikesh B AgasheN K Jain
Apr 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·XinYu WangHiroshi Kiwada
Jul 6, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Sep 18, 2007·Nature Biotechnology·Sai T ReddyJeffrey A Hubbell
Oct 30, 2007·Trends in Immunology·Anne S De Groot, David W Scott
Nov 6, 2007·Biomaterials·Yusuke ArimaHiroo Iwata
Dec 18, 2007·International Journal of Pharmaceutics·Tatsuhiro Ishida, Hiroshi Kiwada
Dec 28, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Jul 1, 2008·International Journal of Pharmaceutics·Hiroyuki KoideNaoto Oku
Jul 26, 2008·Nature Nanotechnology·Marina A Dobrovolskaia, Scott E McNeil
Aug 16, 2008·Journal of Pharmaceutical Sciences·John F CarpenterBarry Cherney
Oct 29, 2008·The Journal of Biological Chemistry·Hideki WatanabeIzumi Kumagai
Oct 30, 2008·Journal of Immunotoxicology·Steven J Swanson
Nov 13, 2008·The Journal of Pharmacy and Pharmacology·Jingxia CuiHaiyan Yang
Apr 11, 2009·Journal of Pharmaceutical Sciences·Renuka ThirumangalathuJohn F Carpenter

❮ Previous
Next ❯

Citations

Jul 30, 2016·Frontiers in Immunology·Dusica Maysinger, Issan Zhang
Aug 17, 2016·Nanomedicine·Kleanthis FytianosBarbara Rothen-Rutishauser
Apr 27, 2017·Annals of the New York Academy of Sciences·Leonie HussaartsJon S B de Vlieger
May 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sónia Alexandra Correia Carabineiro
Sep 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fen-Ying KongWei Wang
Jan 23, 2019·Advanced Healthcare Materials·Eun Sook LeeJae Hyung Park
Oct 26, 2018·Expert Opinion on Drug Metabolism & Toxicology·Anne RodallecJoseph Ciccolini
Apr 30, 2017·Chemical Science·Lev A Dykman, Nikolai G Khlebtsov
May 24, 2019·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Vera BrinksBianca Matthee
Oct 19, 2019·International Journal of Molecular Sciences·See Yee FamWen Siang Tan
Mar 3, 2020·Frontiers in Immunology·Nasser B Alsaleh, Jared M Brown
May 31, 2017·Frontiers in Immunology·Marc J PallardyArmelle Biola-Vidamment
Jul 4, 2020·Scientific Reports·Tamalika KarAnurag P Srivastava
May 13, 2020·Current Osteoporosis Reports·Dominic W MalcolmDanielle S W Benoit
Aug 25, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rachael M CristStephan T Stern
Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renan Vinicius de AraújoJeanine Giarolla
Feb 19, 2019·Frontiers in Immunology·Bengt Fadeel
Apr 25, 2020·Nanomaterials·See Yee FamWen Siang Tan
Apr 4, 2020·Methods : a Companion to Methods in Enzymology·Mahmoud ElsabahyKenneth Oh
Feb 13, 2021·Materials·Bong Han LeeAnton V Naumov
Feb 19, 2021·Drug Delivery and Translational Research·Carmine D'AmicoHélder A Santos
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jenny SpöttelSascha Rohn
Apr 23, 2021·Macromolecular Bioscience·Liwen FuChuanglong He
Jun 5, 2021·Advanced Drug Delivery Reviews·Yiyuan KangLongquan Shao
Feb 16, 2019·Journal of the American Chemical Society·Sampa MaitiWenjun Du
Oct 14, 2019·ACS Biomaterials Science & Engineering·Lili ZhaoIstvan Toth
Aug 28, 2021·Journal of Immunological Methods·João Ricardo Almeida SoaresGerlinde Agate Platais Brasil Teixeira
Oct 5, 2021·Briefings in Bioinformatics·Giulia RussoFrancesco Pappalardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

British Journal of Pharmacology
A N Ilinskaya, Marina A Dobrovolskaia
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Hui-qing Jiang, Yi-fei Chen
The Lancet Infectious Diseases
Lbachir BenMohamedAnthony B Nesburn
© 2022 Meta ULC. All rights reserved