Understanding the Liver-Stage Biology of Malaria Parasites: Insights to Enable and Accelerate the Development of a Highly Efficacious Vaccine

The American Journal of Tropical Medicine and Hygiene
Annie X Mo, Glen McGugan

Abstract

In August 2017, the National Institute of Allergy and Infectious Diseases convened a meeting, entitled "Understanding the Liver-Stage Biology of Malaria Parasites to Enable and Accelerate the Development of a Highly Efficacious Vaccine," to discuss the needs and strategies to develop a highly efficacious, whole organism-based vaccine targeting the liver stage of malaria parasites. It was concluded that attenuated sporozoite platforms have proven to be promising approaches, and that late-arresting sporozoites could potentially offer greater vaccine performance than early-arresting sporozoites against malaria. New knowledge and emerging technologies have made the development of late-arresting sporozoites feasible. Highly integrated approaches involving liver-stage research, "omics" studies, and cutting-edge genetic editing technologies, combined with in vitro culture systems or unique animal models, are needed to accelerate the discovery of candidates for a late-arresting, genetically attenuated parasite vaccine.

References

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Citations

Nov 11, 2019·Parasites & Vectors·Gwendoline DeslyperCelia V Holland
Dec 13, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Brian Gitta, Nicole Kilian
Dec 22, 2020·Frontiers in Cellular and Infection Microbiology·Xiao HeXin-Zhuan Su

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Methods Mentioned

BETA
RNAseq
transgenic
transfection
Assay

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