May 27, 2020

Understanding the mammalian TRAP complex function(s)

Open Biology
Antonietta Russo

Abstract

In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is associated with the ribosome and many accessory components, such as the heterotetrameric translocon-associated protein (TRAP) complex. Recently, microscopic techniques, such as cryo-electron microscopy and cryo-electron tomography, have enabled the determination of the translocation machinery structure. However, at present, there is a lack of understanding regarding the roles of some of its components; indeed, the TRAP complex function during co-translational translocation needs to be established. In addition, TRAP may play a role during unfolded protein response, endoplasmic-reticulum-associated protein degradation and congenital disorder of glycosylation (ssr4 CDG). In this article, I describe the current understanding of the TRAP complex in the light of its possible function(s).

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Mentioned in this Paper

Regulation of Translation by Machinery Localization
Determination Aspects
SEC61 protein
Gene Products, Protein
Structure
Cryoelectron Microscopy
Structure of Lumen of Body System
Endoplasmic Reticulum
SSR4 protein, human
Congenital Disorders of Glycosylation

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