Understanding the molecular mechanisms underlying complex cancer genome rearrangements

Intrinsically Disordered Proteins
Robert Hedlund, Vladimir N Uversky

Abstract

In their recent paper, Malhotra et al. performed a comprehensive analysis of the structural variation breakpoints in 64 cancer genomes from 7 tumor types to find the prevalence and origins of complex genomic rearrangements.(1) Since this work represents a breakthrough in understanding of the molecular mechanisms underlying complex cancer genome rearrangements, we provide a brief overview of this outstanding study.

References

Oct 17, 2002·Journal of Molecular Biology·Lilia M IakouchevaA Keith Dunker
Jun 25, 2008·Annual Review of Biophysics·Vladimir N UverskyA Keith Dunker
Sep 1, 2009·Annual Review of Genomics and Human Genetics·Feng ZhangJames R Lupski

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Methods Mentioned

BETA
SGA

Software Mentioned

MMBIR
HYDRA
SGA

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