Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms

Journal of Neurology
Zhiqiang ZhouXu Zhao

Abstract

Coronavirus disease 2019 (COVID-19), a disease caused by the novel betacoronavirus (SARS-CoV-2), has become a global pandemic threat. The potential involvement of COVID-19 in central nervous system (CNS) has attracted considerable attention due to neurological manifestations presented throughout the disease process. In addition, SARS-CoV-2 is structurally similar to SARS-CoV, and both bind to the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Thus, cells expressing ACE2, such as neurons and glial cells may act as targets and are thus vulnerable to SARS-CoV-2 infection. Here, we have reviewed the neurological characteristics of COVID-19 and summarized possible mechanisms of SARS-CoV-2 invasion of the CNS. COVID-19 patients have presented with a number of different neurological symptoms such as headache, dizziness, hyposmia, and hypogeusia during the course of illness. It has also been reported recently that some cases of COVID-19 have presented with concurrent acute cerebrovascular disease (acute ischemic stroke, cerebral venous sinus thrombosis, cerebral hemorrhage, subarachnoid hemorrhage), meningitis/encephalitis, acute necrotizing hemorrhagic encephalopathy, and acute Guillain-Barré syndrome. Furthermo...Continue Reading

References

Mar 20, 2004·Emerging Infectious Diseases·Kwok-Kwong LauKwok-Yuen Yuen
Jul 27, 2005·The Journal of Experimental Medicine·Jiang GuAnthony S-Y Leong
Sep 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jun XuYong Jiang
Sep 11, 2007·Virus Research·Yong GuoJiang Gu
Feb 15, 2015·Current Opinion in Virology·Phillip A Swanson, Dorian B McGavern
Jun 6, 2017·Journal of Central Nervous System Disease·P Brandon BookstaverSharon Weissman
Nov 18, 2018·Neurochemical Research·Natalia Alenina, Michael Bader
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 26, 2020·International Journal of Oral Science·Hao XuQianming Chen
Feb 28, 2020·Journal of Medical Virology·Yan-Chao LiTsutomu Hashikawa
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zhongliang WangRuiguang Zhang
Mar 18, 2020·Travel Medicine and Infectious Disease·Alfonso J Rodriguez-MoralesUNKNOWN Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea GiacomelliMassimo Galli
Mar 29, 2020·BMJ : British Medical Journal·Rachel E JordanK K Cheng
Apr 3, 2020·The Laryngoscope·Luigi Angelo VairaGiacomo De Riu
Apr 3, 2020·Brain, Behavior, and Immunity·Yeshun WuChun Yang
Apr 7, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Takeshi MoriguchiShinji Shimada
Apr 8, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Apr 9, 2020·The New England Journal of Medicine·Yan ZhangShuyang Zhang
Apr 19, 2020·Chest·Ruchong ChenUNKNOWN Medical Treatment Expert Group for COVID-19
Apr 25, 2020·Curēus·Asia FilatovPatricio S Espinosa
Apr 29, 2020·The New England Journal of Medicine·Thomas J OxleyJohanna T Fifi
May 2, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Fadi Al SaieghM Reid Gooch

❮ Previous
Next ❯

Citations

Jul 31, 2020·ELife·Shumayila Khan, James Gomes
Jul 4, 2020·The American Journal of Tropical Medicine and Hygiene·Laura McArthurCharles A Narh
Sep 3, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kaveh Rahimi
Sep 12, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rafal Butowt, Christopher S von Bartheld
Sep 18, 2020·Journal of Neurology·Fabio Giuseppe MasuccioSolaro Claudio
Jun 18, 2020·Minerva endocrinologica·Subhankar ChatterjeeSanjay Kalra
Sep 22, 2020·Journal of Neurology·Anna Bersano, Leonardo Pantoni
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Adriana PeroDongming Cai
Oct 7, 2020·Brain : a Journal of Neurology·Polyxeni NikolakopoulouAnna Herland
Oct 2, 2020·The Journal of Laryngology and Otology·M ZammitC Webb
Oct 15, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mukesh Kumar, Ajit Kumar Thakur
Nov 21, 2020·Journal of Neuroscience Research·Vladimir N UverskyElrashdy M Redwan
Dec 2, 2020·Medicina·Anna ValenzanoGiuseppe Cibelli
Nov 18, 2020·Brain Sciences·Lyubka TanchevaFerdinando Nicoletti
Aug 2, 2020·Clinical Neurology and Neurosurgery·David J AltschulNeil Haranhalli
Jan 14, 2021·Journal of Biomedical Science·Ioannis P TrougakosMeletios A Dimopoulos
Jan 20, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Júlia Leão Batista Simões, Margarete Dulce Bagatini
Jan 6, 2021·Journal of Psychosomatic Research·Michael HawkinsKathleen Ann Sheehan
Feb 8, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Isaac NúñezSergio Iván Valdés-Ferrer
Feb 16, 2021·Frontiers in Immunology·Edwin Estefan Reza-ZaldívarAlejandro Arturo Canales-Aguirre
Nov 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Isaac CheruiyotJulius A Ogeng'o
Dec 12, 2020·Frontiers in Cellular Neuroscience·Marie-Eve TremblayAlexei Verkhratsky
Jan 26, 2021·Pain Reports·Christine H Meyer-FrießemElena K Enax-Krumova
Feb 7, 2021·Journal of Clinical Medicine·María A Callejon-LeblicSerafin Sanchez-Gomez
Nov 17, 2020·Frontiers in Immunology·Taylon Felipe SilvaMilena Menegazzo Miranda-Sapla
Feb 17, 2021·American Journal of Otolaryngology·Yuce IslamogluMuzaffer Kiris
Sep 9, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Richard A Stein, Lauren M Young
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Islam FayedJeffrey C Mai
Feb 20, 2021·Journal of Neurology·V A Blanco-PalmeroJ González de la Aleja
Feb 27, 2021·Andrology·Andrea SaloniaFrancesco Montorsi
Mar 2, 2021·World Journal of Clinical Cases·Liang HuoHua Wang
Mar 3, 2021·Stem Cell Research & Therapy·Rodrigo N RiedelJulieta L Maymó
Mar 7, 2021·International Journal of Molecular Sciences·Barbara MalinowskaEberhard Schlicker
Mar 7, 2021·Cytokine & Growth Factor Reviews·Narayanappa AmrutaGregory Bix
Mar 13, 2021·BMC Infectious Diseases·Carlos Alfonso Romero-GamerosBaldomero González-Virla
Jan 10, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Theodoros LadopoulosChristos Krogias
Mar 26, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Leticia Sanz-CanalejasNatividad Gómez-Ruiz
Mar 27, 2021·Frontiers in Physiology·Mariana Ferreira SbranaFabio de Rezende Pinna
Jan 6, 2021·Cytokine & Growth Factor Reviews·Inês BarrosCatarina Oliveira Miranda
Mar 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vincenzo LionettiTommaso Angelone

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar
lavage
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Mukesh Kumar, Ajit Kumar Thakur
Frontiers in Cellular Neuroscience
Petra TavčarJernej Jorgačevski
Frontiers in Neurology
Mar Pacheco-HerreroJosé Luna-Muñoz
© 2021 Meta ULC. All rights reserved