Understanding the origin of asthma and its relationship to breastfeeding

Advances in Experimental Medicine and Biology
Marsha Wills-KarpArdythe L Morrow

Abstract

Asthma is a chronic disease of the lung that has been increasing at an alarming rate in industrialized countries around the world over the last few decades. Although considerable progress has been made in our understanding of the underlying pathogenesis of the disease, the exact causes of the increasing prevalence are unknown. Studies suggest that most asthma develops in early childhood and that environmental factors present early in life may be crucial in the development of disease. One potential explanation for the recent epidemic referred to as the "hygiene hypothesis" postulates that factors that have resulted in a reduction in exposure to microbial products and/or infections in the western world may be contributing to this rise in disease prevalence. As early life influences are known to play an important role in establishment of asthma, studies have focused on the interface between mother and child that occurs during gestation and through breastfeeding. In this regard, the body of evidence regarding the relationship between breastfeeding and asthma indicates benefit but with the potential for risk. While providing population-level protection from infections and atopy in infancy and early childhood, breastfeeding might als...Continue Reading

Citations

Jan 23, 2008·Der Internist·J C Virchow
Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology·Joanne M Duncan, Malcolm R Sears
Oct 27, 2010·European Journal of Epidemiology·Sarah J HepworthPatricia A McKinney
Feb 13, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Y MiyakeUNKNOWN Osaka Maternal and Child Health Study Group
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam P MatsonLynn Puddington

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