Understanding the pathogenesis of recessive dystrophic epidermolysis bullosa squamous cell carcinoma

Dermatologic Clinics
Andrew P South, Edel A O'Toole

Abstract

Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa-associated squamous cell carcinoma.

References

Nov 11, 1992·The Journal of Investigative Dermatology·L Bruckner-TudermanT Gedde-Dahl
Apr 1, 1992·Journal of Cutaneous Pathology·J A McGrathR A Eady
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M CorominasA Pellicer
May 1, 1988·Archives of Dermatology·G I GoldbergE A Bauer
Oct 1, 1986·The Journal of Cell Biology·L Y SakaiR E Burgeson
Dec 1, 1974·Archives of Dermatology·W B ReedI B Sneddon
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·W PaulusL Bruckner-Tuderman
Jul 1, 1993·The Journal of Pathology·R VisserF T Bosman
Dec 31, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T KainulainenT Salo
Dec 11, 2002·Clinical and Experimental Dermatology·R Mallipeddi
Feb 6, 2004·Seminars in Cancer Biology·Cheryl L Green, Paul A Khavari
Sep 15, 2004·Current Opinion in Cell Biology·Joni D Mott, Zena Werb
Sep 18, 2004·The Journal of Investigative Dermatology·Jack L ArbiserM Peter Marinkovich
Mar 19, 2005·Science·Susana Ortiz-UrdaPaul A Khavari
May 18, 2005·Burns : Journal of the International Society for Burn Injuries·Areta Kowal-Vern, Bryan K Criswell
Nov 7, 2006·Skinmed·Patrick O EmanuelRobert G Phelps
Jan 25, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·David T WoodleyMei Chen
Mar 12, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y KitaM Mori
Apr 3, 2008·The Journal of Clinical Investigation·Anja FritschLeena Bruckner-Tuderman
Apr 17, 2008·Cancer Research·Mark TranM Peter Marinkovich

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Citations

Mar 1, 2012·Nature Reviews. Cancer·Esther N ArwertFiona M Watt
Mar 4, 2011·Clinical Nuclear Medicine·Ba D Nguyen, Michael C Roarke
Mar 20, 2014·Current Treatment Options in Oncology·Claudia Bejar, Eve Maubec
Nov 28, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jenny BreitenbachJohann W Bauer
Apr 16, 2014·The Journal of Investigative Dermatology·Sho Hiroyasu, Jonathan C R Jones
Mar 25, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Beau R Webber, Jakub Tolar
Aug 9, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Jouni UittoLeena Bruckner-Tuderman
Oct 12, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·I LataifehI Jaradat
Sep 12, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Beau R WebberJakub Tolar
Oct 13, 2020·Experimental Dermatology·Christine ProdingerMartin Laimer

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