Understanding the Pathogenesis of Zika Virus Infection Using Animal Models

Immune Network
Keeton K KrauseMukesh Kumar

Abstract

Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.

References

Jan 1, 1976·The Journal of General Virology·J H WayG S Platt
Jan 1, 1971·Archiv für die gesamte Virusforschung·T M BellH K Narang
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Y FurutaK Shiraki
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICK
Nov 6, 2007·Advances in Immunology·Jamie R Schoenborn, Christopher B Wilson
Jan 17, 2013·Nature Reviews. Microbiology·Mehul S SutharMichael Gale
Oct 3, 2013·Antiviral Research·Yousuke FurutaDale L Barnard
Feb 12, 2014·PLoS Neglected Tropical Diseases·Gilda GrardEric Maurice Leroy
Jan 29, 2016·MMWR. Morbidity and Mortality Weekly Report·Morgan HennesseyJ Erin Staples
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Mar 26, 2016·Science·Nuno Rodrigues FariaPedro F C Vasconcelos
Mar 30, 2016·The American Journal of Tropical Medicine and Hygiene·Shannan L RossiScott C Weaver
Mar 31, 2016·The New England Journal of Medicine·Rita W DriggersOlli Vapalahti
Apr 1, 2016·Clinical Microbiology Reviews·Didier Musso, Duane J Gubler
Apr 1, 2016·MMWR. Morbidity and Mortality Weekly Report·Alexandra M OsterJohn T Brooks
Apr 14, 2016·Cell Host & Microbe·Helen M LazearMichael S Diamond
Apr 14, 2016·The New England Journal of Medicine·Eric D'OrtenzioIsabelle Leparc-Goffart
Apr 20, 2016·PLoS Neglected Tropical Diseases·Matthew T AliotaJorge E Osorio
May 7, 2016·PLoS Neglected Tropical Diseases·Stuart D DowallRoger Hewson
May 20, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marko CuljatMarian E Melish
May 24, 2016·Cell Host & Microbe·Alesha GrantAdolfo García-Sastre
Jun 10, 2016·Nature·Fernanda R CugolaPatricia C B Beltrão-Braga
Jun 29, 2016·Nature Communications·Dawn M DudleyDavid H O'Connor
Jun 30, 2016·Nature·Rafael A LaroccaDan H Barouch
Jul 16, 2016·Science·Neil M FergusonJustin Lessler
Aug 1, 2016·Cell·Haiyan ZhaoDaved H Fremont
Aug 5, 2016·MMWR. Morbidity and Mortality Weekly Report·Laura AdamsBrenda Rivera-Garcia
Aug 26, 2016·PLoS Neglected Tropical Diseases·Zachary A KlaseRobert Malone
Sep 11, 2016·Cell Reports·Jonathan J MinerRajendra S Apte
Nov 1, 2016·Nature Medicine·Kristina M Adams WaldorfLakshmi Rajagopal
Sep 16, 2016·MMWR. Morbidity and Mortality Weekly Report·William L WalkerJ Erin Staples
Sep 30, 2016·MMWR. Morbidity and Mortality Weekly Report·Anna LikosCeleste Philip
Oct 26, 2016·EBioMedicine·Xiao-Feng LiCheng-Feng Qin
Nov 1, 2016·Nature Medicine·Christa E OsunaJames B Whitney
Oct 7, 2016·Science·Kimberly A DowdBarney S Graham
Oct 18, 2016·Open Forum Infectious Diseases·Yong-Qiang DengCheng-Feng Qin
Nov 1, 2016·Nature·Jennifer GoveroMichael S Diamond

❮ Previous
Next ❯

Citations

Dec 19, 2018·The American Journal of Tropical Medicine and Hygiene·Rodion GorchakovKristy O Murray
Jan 27, 2019·The Journal of Comparative Neurology·Elizabeth B HutchinsonSharon L Juliano
Jun 28, 2018·Scientific Reports·Ajeet KaushikMadhavan Nair
May 30, 2017·Asian Pacific Journal of Tropical Medicine·Amjad AliMuhammad Idrees
Dec 27, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Irena TsuiAndrea A Zin
Feb 7, 2018·Current Opinion in Obstetrics & Gynecology·Nahida ChakhtouraCatherine Y Spong
May 12, 2019·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Saiee F Nithiyanantham, Alaa Badawi
Mar 13, 2018·Frontiers in Neurology·Angelina Kakooza-MwesigeJulius J Lutwama
Oct 6, 2020·Veterinary Pathology·Lisa G LaniganBrad Bolon
Apr 6, 2021·Frontiers in Immunology·Han WuDaishu Han
Sep 1, 2021·Expert Opinion on Drug Discovery·Cecilia BenazzatoPatricia Cristina Baleeiro Beltrão-Braga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Biochemical Sciences
Yi Shi, George F Gao
Pathogens and Global Health
Carlo TicconiGiovanni Rezza
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Rodolphe HamelDorothée Missé
© 2022 Meta ULC. All rights reserved