Abstract
The current challenge in prostate cancer (PCa) focal therapy indication and planning is how to accurately estimate tumor parameters such as volume, extent and grade. In addition to biopsy results, MRI provides an estimation of PCa contour, volume and histopathological characteristics such as presence of high Gleason grade. Among MRI sequences, diffusion-weighted imaging with apparent diffusion coefficient map is the sequence that showed the best results for cancer aggressiveness characterization. It was shown that the higher the Gleason score, the lower the apparent diffusion coefficient value. However, accuracy is not sufficient for peripheral zone cancers to be validated for clinical decision and it was not enough investigated for transition zone cancers. Analysis of tumor extent showed a significant underestimation of tumor volume by imaging and this finding should be taken into consideration when planning focal therapy procedures. Pathological implications of MRI for focal therapy planning are significant but not mature enough to be validated. Future research should aim to quantify cellularity and architectural patterns of PCa Gleason system in correlation with signal abnormalities for better assessment of tumor aggressiven...Continue Reading
References
Nov 18, 2008·Radiology·Deanna L LangerMasoom A Haider
Mar 1, 2012·Journal of Magnetic Resonance Imaging : JMRI·Kazuhiro KitajimaKazuro Sugimura
Apr 14, 2012·The Journal of Urology·Andrew B RosenkrantzSamir S Taneja
Apr 25, 2012·European Radiology·Gregor ThörmerHarald Busse
Aug 21, 2012·The Journal of Urology·Baris TurkbeyPeter A Pinto
Aug 28, 2012·Radiology·Geert J S LitjensHenkjan J Huisman
Feb 9, 2013·Radiology·Yahui PengAytekin Oto
Mar 16, 2013·European Radiology·Flavie BratanOlivier Rouvière
Jul 24, 2013·Radiology·Sung Il JungOguz Akin
Sep 3, 2013·European Radiology·Michael QuentinDirk Blondin
Sep 12, 2013·International Urology and Nephrology·Hyeyeol BaeKazunori Kihara
Oct 22, 2013·Cancer Investigation·Rocchina CaivanoAldo Cammarota
Jan 22, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mekhail AnwarFergus V Coakley
Jan 23, 2014·BJU International·Erik RudHeidi B Eggesbø
Jan 29, 2014·Urology·Karim ChamieRobert E Reiter
Jan 31, 2014·Radiology·Olivio F DonatiOguz Akin
Mar 13, 2014·Journal of Magnetic Resonance Imaging : JMRI·Andrew B RosenkrantzFang-Ming Deng
Mar 29, 2014·BJU International·Julien Le NobinAndrew B Rosenkrantz
Citations
Nov 25, 2016·Future Oncology·Adil OuzzaneGuillaume Ploussard
Apr 7, 2017·Journal of Magnetic Resonance Imaging : JMRI·Olivier HelfrichArnauld Villers
Aug 22, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Arjun SivaramanXavier Cathelineau
Jul 4, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jurgen J Fütterer
Jul 18, 2017·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Hossein Jadvar
Jul 14, 2018·World Journal of Urology·Eric BarretOlivier Rouvière
Jun 28, 2021·Urologic Oncology·Zhien ZhouZhigang Ji