Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics

Journal of Pharmaceutical Sciences
Leslie Z Benet, Hsin-Fang Wu

Abstract

Here we address the potential difference in rosuvastatin pharmacokinetics in Asians vs. whites. Our prospective study, reported in this issue, shows no ethnic difference when all subjects are wild-type for OATP1B1 and BCRP. We argue that although our study may be under powered to prove no ethnic difference, and that further confirmatory study is required, the virtual clinical study analysis, also reported in this issue, does not contradict the results of our prospective clinical study and that previous retrospective analysis of clinical studies does not include enough relevant subjects to conclude that wild-type OATP1B1 and BCRP do still demonstrate ethnic differences.

References

Oct 4, 2005·Clinical Pharmacology and Therapeutics·Edmund LeeDennis Schneck
Jun 21, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei ZhangHong-Hao Zhou
May 29, 2009·Clinical Pharmacology and Therapeutics·J E KeskitaloM Niemi
Mar 26, 2011·British Journal of Clinical Pharmacology·Alicia J AllredEdmund Lee

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