Understanding the Relationship between Chronic Systemic Disease and Lichen Sclerosus Urethral Strictures

The Journal of Urology
Bradley A EricksonTrauma and Urologic Reconstructive Network of Surgeons

Abstract

Lichen sclerosus is a chronic, inflammatory skin condition of the genitalia of unknown origin that accounts for nearly 10% of urethral stricture disease. In this study we determine systemic comorbidities associated with lichen sclerosus in men. We analyzed data from 1,151 men who were enrolled in a multi-institutional prospective urethroplasty outcomes database. Individuals were grouped by stricture etiology, and baseline demographics, medical histories and patient reported outcome measures were retrospectively compared across groups. Of the 1,151 men in the database 81 (7.0%) were noted to have lichen sclerosus related urethral stricture disease. Average patient age was 46.06 ± 16.52 years, with those with lichen sclerosus being significantly older than those without lichen sclerosus (51.26 ± 13.84 vs 45.68 ± 16.64, p = 0.0011). Men with lichen sclerosus were more likely to have hypertension, hyperlipidemia and diabetes, and to use tobacco products. Controlling for age, men with lichen sclerosus related urethral stricture disease had a higher body mass index (aOR 1.089, 95% CI 1.050-1.130), and were more likely to have hypertension (aOR 2.028, 1.21-3.41) and be active tobacco users (aOR 2.0, 1.36-3.40). Mean preoperative patie...Continue Reading

References

Mar 5, 1998·Journal of the American Academy of Dermatology·D Parsad, R Saini
Jun 20, 1998·British Journal of Urology·S N Venn, A R Mundy
May 29, 1999·Lancet·J J Powell, F Wojnarowska
Jul 18, 2003·Lancet·Noritaka OyamaJohn A McGrath
Sep 8, 2005·The Journal of Urology·Patricio C GargolloDavid A Diamond
Jul 11, 2006·Archives of Gynecology and Obstetrics·Hans J StrittmatterSonja R Blecken
Oct 16, 2007·The Journal of Urology·Jennifer M PuglieseAndrew C Peterson
Dec 19, 2009·The Journal of Urology·Benjamin N BreyerBryan B Voelzke
Mar 6, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·V ShermanF Wojnarowska
Dec 21, 2010·The Journal of Urology·Dayne M Nelson, Andrew C Peterson
Mar 15, 2011·Clinics in Dermatology·Lior Sagi, Henri Trau
Apr 17, 2012·The Journal of Urology·Timothy J Tausch, Andrew C Peterson
Dec 12, 2012·European Urology·Kerri T BarnesAmit Gupta
Jan 19, 2013·American Journal of Clinical Dermatology·Susanna K Fistarol, Peter H Itin
May 30, 2013·American Society of Clinical Oncology Educational Book·Penelope M Webb
Nov 26, 2013·Urology·Laurence StewartRamon Virasoro
Mar 25, 2014·The Journal of Urology·Joceline S LiuChris M Gonzalez
Aug 6, 2014·Autoimmunity Reviews·Mathilde VersiniYehuda Shoenfeld
Sep 23, 2014·The Journal of Clinical Investigation·Jordan S Pober
May 6, 2015·The Canadian Journal of Cardiology·Augusto C MontezanoRhian M Touyz
May 20, 2015·World Journal of Diabetes·Iqra HameedBashir A Ganai

❮ Previous
Next ❯

Citations

Mar 20, 2016·The Journal of Urology·Thomas G Smith
Mar 13, 2016·The Journal of Urology·Drew A PalmerAlex J Vanni
Jun 11, 2020·F1000Research·Rachel KwokSuks Minhas
Dec 7, 2019·World Journal of Urology·Amanda S J Chung, Oscar A Suarez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.