Understanding the relationship between olfactory-specific quality of life, objective olfactory loss, and patient factors in chronic rhinosinusitis

International Forum of Allergy & Rhinology
Jose L MattosZachary M Soler

Abstract

Chronic rhinosinusitis (CRS) significantly impacts olfaction. However, the relationship between objective olfaction and patient-reported olfactory-specific quality of life (QOL) is not well understood. Furthermore, objective olfactory testing can be time consuming, so we sought to determine if patient-reported olfactory QOL can be used as screening tool for olfactory dysfunction. Olfactory dysfunction was evaluated in 109 patients with CRS using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) and the Sniffin' Sticks Test, assessing for olfactory threshold, discrimination, identification, and overall composite scores (TDI; composite score of threshold, discrimination, and identification). Regression analysis was performed to correlate olfactory metrics and patient and disease-specific factors with QOD-NS scores. Optimal QOD-NS scores to classify patients based upon objective olfactory function were established. Bivariate and multivariate regression analyses of QOD-NS and CRS-associated comorbidities, objective measures of disease, demographics, and CRS-specific QOL were performed. Non-white race, depression, and worse 22-item Sino-Nasal Outcome Test (SNOT-22) scores correlated with worse QOD-NS scores (p < ...Continue Reading

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Citations

Apr 11, 2018·International Forum of Allergy & Rhinology·Jose L MattosZachary M Soler
Apr 9, 2018·Thorax·Joanne Rimmer
Jun 22, 2019·American Journal of Rhinology & Allergy·Jensine M LamiraRodney J Schlosser
Aug 21, 2019·International Forum of Allergy & Rhinology·Jose L MattosZachary M Soler
Feb 6, 2020·International Forum of Allergy & Rhinology·Andrew J ThomasTimothy L Smith
Dec 4, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Kristine A Smith, Jeremiah A Alt
Jul 2, 2020·The Laryngoscope·Deborah X XieNicholas R Rowan
Aug 5, 2020·American Journal of Rhinology & Allergy·Vincent M DesiatoRodney J Schlosser
Sep 12, 2020·American Journal of Rhinology & Allergy·Vincent M DesiatoRodney J Schlosser
Dec 6, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ken OkazakiMasafumi Sakagami
Nov 30, 2018·International Forum of Allergy & Rhinology·Nicholas R RowanRodney J Schlosser
Jul 22, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Dawei WuYongxiang Wei
Jan 4, 2020·International Forum of Allergy & Rhinology·Rodney J SchlosserZachary M Soler
Apr 17, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Anna Oleszkiewicz, Thomas Hummel
Apr 21, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A OleszkiewiczT Hummel
Apr 30, 2020·American Journal of Rhinology & Allergy·Rodney J SchlosserZachary M Soler
Dec 29, 2020·Laryngoscope Investigative Otolaryngology·Xiaoguang YanThomas Hummel
Apr 13, 2020·Immunology and Allergy Clinics of North America·Omar G Ahmed, Nicholas R Rowan

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