Understanding the role of maternal diet on kidney development; an opportunity to improve cardiovascular and renal health for future generations

Nutrients
Ryan James Wood-BradleyJames Andrew Armitage

Abstract

The leading causes of mortality and morbidity worldwide are cardiovascular disease (high blood pressure, high cholesterol and renal disease), cancer and diabetes. It is increasingly obvious that the development of these diseases encompasses complex interactions between adult lifestyle and genetic predisposition. Maternal malnutrition can influence the fetal and early life environment and pose a risk factor for the future development of adult diseases, most likely due to impaired organogenesis in the developing offspring. This then predisposes these offspring to cardiovascular disease and renal dysfunction in adulthood. Studies in experimental animals have further illustrated the significant impact maternal diet has on offspring health. Many studies report changes in kidney structure (a reduction in the number of nephrons in the kidney) in offspring of protein-deprived dams. Although the early studies suggested that increased blood pressure was also present in offspring of protein-restricted dams, this is not a universal finding and requires clarification. Importantly, to date, the literature offers little to no understanding of when in development these changes in kidney development occur, nor are the cellular and molecular mec...Continue Reading

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Citations

May 10, 2018·Archives of Physiology and Biochemistry·Asmaa Mohammed ShamseldeenSamaa Samir Kamar
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Methods Mentioned

BETA
cRET
histone acetylation
transgenic

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