Understanding the Surgical Margin: A Molecular Assessment

Oral and Maxillofacial Surgery Clinics of North America
David J Clark, Li Mao

Abstract

The inclusion of molecular characteristics into surgical margin analysis may not only yield a more sensitive and accurate assessment of the cells in these margins, but may also provide insight into their impacts on patients' postoperative prognosis. This concept of the "molecular surgical margin" is advantageous, as it integrates recent advances in our understanding of head and neck carcinogenesis, while also retaining the established methodology of histopathology. This multidisciplinary approach may facilitate the development of a uniform criterion for defining the surgical margin, which will likely result in a reduced recurrence rate and improved overall patient survival.

Citations

Apr 2, 2019·Oral Diseases·Giancarlo TirelliFrancesca Boscolo Nata
Jun 9, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Mamata S KamatUma V Datar
Sep 7, 2018·Case Reports in Pathology·Carla Bento Nelem-ColturatoAlvaro Henrique Borges
Aug 4, 2020·Clinical Proteomics·David J Clark, Hui Zhang
Apr 10, 2020·Cancer Letters·Antoine GalmicheFlorian Clatot
May 18, 2021·Indian Journal of Surgical Oncology·Madhabananda KarBirendranath Banerjee
Jul 3, 2021·Cancers·Bruna Pereira SorrocheLidia Maria Rebolho Batista Arantes

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