PMID: 9532334Apr 9, 1998Paper

Understanding the thyrotropin receptor function-structure relationship

Baillière's Clinical Endocrinology and Metabolism
Jane SandersB Rees Smith

Abstract

The thyrotropin (TSH) receptor (TSHR) is a key protein in the control of thyroid function and a major thyroid autoantigen. Recently, molecular cloning of the receptor has been carried out and we now review the impact of this work on our understanding of the physiology and pathophysiology of the TSHR. Analysis of recombinant TSHR proteins expressed in prokaryotic and eukaryotic systems has indicated that post-translational processing is important for the formation of active receptors. Studies of TSHR glycosylation have shown that a 'mature' form of the receptor containing mainly complex-type sugar residues is principally involved in TSH and TSHR autoantibody (TRAb) binding. In addition, the processing of the TSHR peptide chain into two subunits observed with native TSHR has been confirmed using recombinant TSHR. However, despite considerable efforts in many laboratories, the binding site(s) for TSH and TRAb on the TSHR have not been well characterized as yet and lessons learned from the discovery of naturally occurring amino acid mutations of the TSHR confirm the complexity of the hormone and autoantibody binding sites. Future progress in producing large amounts of pure TSHR as well as monoclonal TRAbs, followed by crystallograp...Continue Reading

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Citations

Feb 21, 2003·Thyroid : Official Journal of the American Thyroid Association·Jane SandersBernard Rees Smith
Feb 21, 2003·Thyroid : Official Journal of the American Thyroid Association·Jennifer JeffreysBernard Rees Smith
Feb 24, 2001·Thyroid : Official Journal of the American Thyroid Association·Y OdaB R Smith
Aug 2, 2005·Thyroid : Official Journal of the American Thyroid Association·J SandersB Rees Smith
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Bernard Rees SmithJadwiga Furmaniak
Jul 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Jane SandersBernard Rees Smith
Mar 30, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Juan C GalofréRauf Latif
Jul 3, 2010·Autoimmunity Reviews·Klaus ZöphelMatthias Schott
Nov 28, 2001·Protein Expression and Purification·B E BusuttilA G Frauman
Jan 29, 2019·Journal of Molecular Endocrinology·Jennifer Miller-GallacherBernard Rees Smith
Jul 15, 2005·Molecular Pharmacology·Romy FrenzelRalf Paschke
Oct 18, 2002·European Journal of Biochemistry·Sandrine Siffroi-FernandezJean-Louis Franc
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·J SandersB R Smith
Apr 1, 2013·Auto- Immunity Highlights·Jadwiga FurmaniakBernard Rees Smith
Jan 23, 2019·Frontiers in Endocrinology·Simeng SunTerry F Davies
Jan 22, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Charles H Emerson, Mira S T Torres
Feb 13, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jadwiga FurmaniakBernard Rees Smith
Sep 12, 2002·The Journal of Biological Chemistry·Rauf LatifTerry F Davies
Jun 30, 2000·Endocrinology and Metabolism Clinics of North America·P N Graves, T F Davies

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