Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective

British Journal of Pharmacology
Debashree BasudharDavid A Wink

Abstract

Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE2 , respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE2 in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.

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Citations

Dec 18, 2018·British Journal of Pharmacology·Louis J Ignarro
Dec 7, 2018·Journal of Experimental & Clinical Cancer Research : CR·Ying LiuFang Tian
Feb 22, 2021·Molecular and Cellular Endocrinology·Thaysa Kelly Barbosa VieiraCarlos Alberto de Carvalho Fraga
Apr 17, 2021·Communications Biology·Anne C GilmoreWilliam F Heinz
Jul 3, 2021·International Journal of Molecular Sciences·Christopher L McGinityDavid A Wink
Sep 14, 2021·Antioxidants & Redox Signaling·Bo LiAlexander Ryan Lippert
Nov 6, 2021·Science Advances·Rossella MarulloLeandro Cerchietti

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