Understanding the Unfolded Protein Response in the Pathogenesis of Asthma

Frontiers in Immunology
Prabuddha S PathinayakePeter A B Wark

Abstract

Asthma is a heterogeneous, chronic inflammatory disease of the airways. It is a complex disease with different clinical phenotypes and results in a substantial socioeconomic burden globally. Poor understanding of pathogenic mechanisms of the disease hinders the investigation into novel therapeutics. Emerging evidence of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) has demonstrated previously unknown functions of this response in asthma development. A worsening of asthmatic condition can be brought on by stimuli such as oxidative stress, pathogenic infections, and allergen exposure. All of which can induce ER stress and activate UPR leading to activation of different inflammatory responses and dysregulate the innate immune functions in the airways. The UPR as a central regulator of asthma pathogenesis may explain several unknown mechanism of the disease onset, which leads us in new directions for future asthma treatments. In this review, we summarize and discuss the causes and impact of ER-UPR in driving the pathogenesis of asthma and highlight its importance in clinical implications.

References

Sep 19, 2000·Thorax·R Dworski
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·P ParediP J Barnes
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·R A DweikS C Erzurum
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R DworskiJ R Sheller
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·H IijimaD H Eidelman
Jul 19, 2001·Nature·A M ReimoldL H Glimcher
Oct 9, 2001·The European Respiratory Journal·G CaramoriI M Adcock
Nov 1, 2001·Respiratory Research·P J Barnes
Nov 8, 2001·European Journal of Pharmacology·W MacNee
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Axel TrautmannCezmi A Akdis
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing XieBoris Yoffe
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Nov 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Wei YanMichael G Katze
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Qutayba HamidRedwan Moqbel
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Ahmad NadeemHanumanthrao G Raj
Dec 3, 2003·Virchows Archiv : an International Journal of Pathology·Toshiharu HayashiKeiko Hasegawa
Feb 6, 2004·The Journal of Cell Biology·Benjamin P Tu, Jonathan S Weissman
Jun 24, 2004·Seminars in Cell & Developmental Biology·Julian Downward
Sep 8, 2004·Molecular Cell·Cole M HaynesAntony A Cooper
Nov 3, 2004·The Journal of Cell Biology·Yukio KimataKenji Kohno
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Stefan J Riedl, Yigong Shi
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Lisa G WoodPeter G Gibson
Jan 20, 2005·Molecular and Cellular Biology·Jingshi ShenRon Prywes
Mar 23, 2005·The Journal of Experimental Medicine·Peter A B WarkDonna E Davies
Sep 24, 2005·International Archives of Allergy and Immunology·Axel TrautmannCezmi A Akdis
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Esteban J Morcillo, Julio Cortijo
Mar 2, 2006·The European Respiratory Journal·D W DenningR M Niven
Apr 1, 2006·American Journal of Respiratory and Critical Care Medicine·Patryk SzulakowskiEllen M Drost
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie CarriereJean-Philippe Girard
Feb 10, 2007·The FEBS Journal·Hiderou Yoshida
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Lance CohenUNKNOWN NHLBI Severe Asthma Research Program (SARP)
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Sep 19, 2007·The Journal of Experimental Medicine·Neal N IwakoshiLaurie H Glimcher
Sep 28, 2007·Annual Review of Microbiology·Thomas Wileman
Nov 6, 2007·Antioxidants & Redox Signaling·Jyoti D Malhotra, Randal J Kaufman
Dec 15, 2007·American Journal of Respiratory Cell and Molecular Biology·Steven G KelsenSalim Merali

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Citations

Sep 27, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Dawn M Cooper, Matthew Loxham
Apr 8, 2020·American Journal of Respiratory and Critical Care Medicine·Jose L GomezGeoffrey L Chupp
Nov 28, 2018·Allergy, Asthma & Immunology Research·Byung Keun KimHeung Woo Park
Feb 6, 2020·Frontiers in Cell and Developmental Biology·Philippe Delmotte, Gary C Sieck
Sep 12, 2020·American Journal of Respiratory Cell and Molecular Biology·Sanaz DastghaibAmir A Zeki
Jan 6, 2021·International Journal of Molecular Sciences·Debanjali DasguptaGary C Sieck
Aug 14, 2020·Free Radical Biology & Medicine·Rafael Martinez-CarrascoM Elizabeth Fini
Oct 15, 2020·Journal of Cachexia, Sarcopenia and Muscle·Adeline DollyStéphane Servais
Jan 12, 2021·Frontiers in Immunology·Christopher R LuthersAndrew L Snow
Nov 21, 2020·Nature Reviews. Cancer·Xi Chen, Juan R Cubillos-Ruiz
Feb 14, 2021·Drug Discovery Today·Christian Bailly, Gérard Vergoten
Jun 24, 2021·Scientific Reports·J M SweeterJ D Dickinson
Oct 9, 2021·The Journal of Allergy and Clinical Immunology·Rui ChenJudith C W Mak

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Methods Mentioned

BETA
protein folding
nuclear translocation
glycosylation
ubiquitination

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