Understanding the viscoelastic behavior of arterial elastin in glucose via relaxation time distribution spectrum

Journal of the Mechanical Behavior of Biomedical Materials
Yunjie WangYanhang Zhang

Abstract

Elastin is a critical extracellular matrix protein that provides many biological tissues with resilience. In elastic arteries such as aorta, elasticity is crucial for energy storage and transmission of the pulsatile blood flow. As one of the main mechanisms of aging, non-enzymatic glycation can greatly compromise the mechanical properties of the long-lived elastin. In this study, effect of glucose on the viscoelastic behavior of purified porcine aortic elastin was investigated through stress relaxation tests and the corresponding relaxation time distribution spectra. Elastin was incubated in 2M glucose solution at 37°C for 4, 7, 14, 21 or 28 days. Biaxial stress relaxation tests were performed to study the viscoelastic property of elastin. Elastin samples with glucose treatment show increased stress relaxation with incubation time. Continuous relaxation time distribution spectra were obtained from the stress relaxation data using Tikhonov regularization method. Generally the spectra of both untreated and treated elastin have a broad range of relaxation time constants and multiple peaks located between 0.1-10,000s. The intensity of the short-term peak (0.1-10s) increases after glucose exposure whereas the intensity of the long-t...Continue Reading

References

Feb 1, 1991·Clinical Cardiology·C J SchwartzR M Nerem
May 1, 1990·American Journal of Respiratory Cell and Molecular Biology·W C Parks, S B Deak
Jul 5, 1990·Biopolymers·M A Lillie, J M Gosline
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Z IndikJ Rosenbloom
Mar 1, 1983·Ultrastructural Pathology·D W Urry
May 1, 1993·Biorheology·M A Lillie, J M Gosline
Aug 1, 1996·Diabetologia·T J SimsA J Bailey
Nov 1, 1996·Biopolymers·M A Lillie, J M Gosline
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·L Debelle, A M Tamburro
Nov 27, 1999·Biochimie·L Debelle, A J Alix
Jun 16, 2001·Journal of Vascular Research·N StergiopulosS E Greenwald
Nov 29, 2001·Journal of the American Chemical Society·B LiV Daggett
Mar 26, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John GoslineKen Savage
May 16, 2002·Biopolymers·M A Lillie, J M Gosline
Jun 6, 2003·Journal of Muscle Research and Cell Motility·Bin Li, Valerie Daggett
May 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Xiaomei Guo, Ghassan S Kassab
Jan 18, 2007·Journal of Biomechanical Engineering·Jun LiaoMichael S Sacks
Jun 16, 2007·Journal of Biomechanics·John A StellaMichael S Sacks
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Carmel M McEnieryAlbert P Avolio
Jun 2, 2009·Annals of Biomedical Engineering·Yu Zou, Yanhang Zhang
Aug 13, 2010·The Journal of Surgical Research·Ming-Jay Chow, Yanhang Zhang
Oct 22, 2010·Biomechanics and Modeling in Mechanobiology·Yu Zou, Yanhang Zhang
Jun 6, 2013·Journal of Biomechanics·Hannah WeisbeckerGerhard A Holzapfel
Nov 16, 2013·Journal of Biomechanical Engineering·Bin XuYanhang Zhang
Jul 1, 2012·Journal of Biomechanical Engineering·Yu Zou, Yanhang Zhang
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuanming LiuJiangyu Li
Apr 12, 2015·Biophysical Journal·Moshe C SilversteinGregory S Boutis
Jun 5, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Yunjie WangYanhang Zhang
Nov 3, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Behzad BabaeiGuy M Genin
Mar 27, 2016·Acta Biomaterialia·Behzad BabaeiGuy M Genin
Sep 21, 2016·Biophysical Chemistry·Kubra BiliciGregory S Boutis

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Citations

Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Phani Kumari ParitalaZhiyong Li
Feb 16, 2021·Experimental Mechanics·R WangY Zhang
May 25, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Behzad BabaeiGuy M Genin
Jul 23, 2021·Journal of the Mechanical Behavior of Biomedical Materials·J G Murphy, K R Rajagopal
Aug 1, 2021·Journal of the Mechanical Behavior of Biomedical Materials·J G Murphy, K R Rajagopal

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