Oct 19, 2011

Understanding type 1 diabetes through genetics: advances and prospects

Nature Reviews. Genetics
Constantin Polychronakos, Quan Li

Abstract

Starting with early crucial discoveries of the role of the major histocompatibility complex, genetic studies have long had a role in understanding the biology of type 1 diabetes (T1D), which is one of the most heritable common diseases. Recent genome-wide association studies (GWASs) have given us a clearer picture of the allelic architecture of genetic susceptibility to T1D. Fine mapping and functional studies are gradually revealing the complex mechanisms whereby immune self-tolerance is lost, involving multiple aspects of adaptive immunity. The triggering of these events by dysregulation of the innate immune system has also been implicated by genetic evidence. Finally, genetic prediction of T1D risk is showing promise of use for preventive strategies.

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References

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Citations

Mentioned in this Paper

Genome-Wide Association Study
Immune System
Quantitative Trait Loci
Major Histocompatibility Complex
Adaptive Immunity
Diabetes Mellitus, Insulin-Dependent
Diabetes, Autoimmune
Entire Immune System
Alleles
Genetic Predisposition to Disease

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