Underuse of self-controlled designs in pharmacoepidemiology in electronic healthcare databases: a systematic review

Pharmacoepidemiology and Drug Safety
Nathalie GaultFlorence Tubach

Abstract

The self-controlled (SC) designs offer the advantage of inherently controlling for time-invariant confounders, which may not be collected in electronic healthcare databases. To be valid, the design requires that some characteristics must be present. Recommendations for their use have been published in 2012, which encourage their implementation when these key characteristics are valid. We aimed at describing the potentially missed opportunities for the use of SC in pharmacoepidemiological studies on electronic healthcare databases. We searched Medline for the articles published in two different 6-month periods before and after the 2012 recommendations. The potentially opportunity for the use of SC design is based on major required characteristics (abrupt onset event, rare or recurrent event, and acute or intermittent exposure). In total, 94 papers in 2011 were analysed and 106 in 2014. SC designs were rarely used (2% in 2011 and 1% in 2014). A potentially missed opportunity for SC use was found in 16% of papers in 2011 and 15% in 2014. We found that SC designs were underused and identified situations in which they could have been applied, but were not. Their use should be encouraged.

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Citations

Oct 28, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robert W Platt
Jul 31, 2019·Pharmacoepidemiology and Drug Safety·Yuelian SunJørn Olsen
May 26, 2020·The Australian and New Zealand Journal of Psychiatry·Christopher RohdeJimmi Nielsen
Feb 10, 2017·BMC Medical Research Methodology·Nathalie GaultFlorence Tubach

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