Abstract
Atrial fibrillation, the most common chronic arrhythmia, results in an increased risk of stroke. Anticoagulation therapy can reduce this risk, but appears to be underused. The objective of this study was to examine the use of warfarin and prevalence of stroke in patients with rheumatic, nonrheumatic valvular and nonvalvular atrial fibrillation. Between January 1993 and December 1998, 457 chronic atrial fibrillation patients with continuous follow-up in our hospital were identified as having rheumatic heart disease (n = 114): nonrheumatic valvular disease (n = 65); or nonvalvular disease (n = 278). Warfarin was used less often in patients with nonrheumatic valvular (16.7%) and nonvalvular diseases (20.1%) than in those with rheumatic heart disease (81.6%, p < 0.001). In contrast, the prevalence of stroke among patients with nonvalvular disease was 40.3% which was similar to the 33.3% found in patients with rheumatic heart disease but significantly higher than the 24.6% found in patients with nonrheumatic valvular disease (p < 0.05). A history of stroke did not alter the trend of use of warfarin among the three groups of patients. Only 20.6% of patients on warfarin received monthly monitoring of prothrombin time. In conclusion, t...Continue Reading
References
Nov 12, 1992·The New England Journal of Medicine·M D EzekowitzM J Radford
Jan 1, 1992·Annals of Internal Medicine
Aug 1, 1991·Journal of the American College of Cardiology·S J ConnollyC Joyner
Nov 29, 1990·The New England Journal of Medicine·UNKNOWN Boston Area Anticoagulation Trial for Atrial Fibrillation InvestigatorsJ Philip Kistler
Feb 13, 1995·Archives of Internal Medicine·D C McCroryE L Pritchett
Nov 20, 1993·Lancet·A Laupacis
Jul 11, 1994·Archives of Internal Medicine
Jan 1, 1994·British Heart Journal·G Y LipF G Dunn
Mar 15, 1996·Circulation·E N PrystowskyD G Wyse
Aug 22, 1996·The New England Journal of Medicine·E M HylekD E Singer
Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·F E MunschauerA Castilone
Apr 7, 1998·The American Journal of Medicine·D Bush, M Tayback
Dec 16, 1998·Annals of Internal Medicine·C StöllbergerJ Slany
Dec 16, 1998·Annals of Internal Medicine
Jun 20, 1998·Annals of Internal Medicine·C W ChiangC H Chang
Citations
Jul 12, 2005·Cerebrovascular Diseases·Chun-ming CheungChen-ya Huang
Jun 15, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi OgawaKazuhiro Kanmuri
Oct 8, 2009·International Heart Journal·Borut JugIrena Keber
May 13, 2014·European Journal of Clinical Pharmacology·Durga BistaGregory Peterson
Aug 6, 2015·Journal of cardiology·Iyn-Hyang LeeNam Kyung Je
Aug 30, 2008·Pharmacotherapy·Nita A Limdi, David L Veenstra
Feb 22, 2014·Archives of Cardiovascular Diseases·Habib GamraUNKNOWN RealiseAF investigators
Apr 2, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Esther W ChanIan C K Wong
May 23, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Xue LiEsther W Chan
Jul 10, 2016·International Journal of Cardiology·Eun Joo ChoiNam Kyung Je
Nov 23, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Hsiu-Chin YuChi-Hsiao Yeh
Sep 25, 2015·Medicine·Yi-Pin Lin, Teng-Yeow Tan