Underutilization of gastroprotection for at-risk patients undergoing percutaneous coronary intervention: Spain compared with the United States

Alimentary Pharmacology & Therapeutics
R Casado-ArroyoA Lanas

Abstract

Proton pump inhibitors (PPIs) are the preferred agents for the prevention of aspirin-associated upper gastrointestinal bleeding (UGIB). Data are limited to determine whether PPIs are being used to reduce UGIB risk. To evaluate the implementation of PPI treatment to reduce the GI risk in two cardiology centres from Europe and the United States. A retrospective cross-sectional study was carried out at the University of Michigan and University Hospital-Zaragoza in 429 consecutive patients hospitalized for percutaneous coronary intervention (PCI) on dual antiplatelet therapy. Admission for PPI co-therapy was similar (34% vs. 30%) in both centres. At discharge, the proportion of high-risk patients receiving PPI therapy in the Spanish centre (75.4%) was higher than their American peers (55.6%) (OR: 2.5; 95% CI; 1.3-4.7). No differences in PPI prescription rates were found among Spanish patients with/without GI risk factors. The opportunity to initiate PPI co-therapy in high-risk patients was missed in 81.8% (36/44) of those not on PPI at admission in US patients vs. 24.1% (19/79) (P < 0.0001) in Spanish patients. There are important differences concerning PPI prescription and risk stratification in the two centres when managing PCI p...Continue Reading

References

Jun 1, 1996·Gastroenterology Clinics of North America·J M Scheiman
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Jan 22, 2005·The New England Journal of Medicine·Francis K L ChanJoseph J Y Sung
Jan 30, 2007·Current Medical Research and Opinion·Angel Lanas, James Scheiman
Mar 7, 2007·The American Journal of Gastroenterology·Angel LanasUNKNOWN Investigators of the Asociación Española de Gastroenterología (AEG)
May 15, 2007·Lancet·James M Scheiman, A Mark Fendrick
Aug 19, 2007·Circulation·Anthony A Bavry, Deepak L Bhatt
Dec 25, 2008·The New England Journal of Medicine·Tabassome SimonUNKNOWN French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
Mar 5, 2009·JAMA : the Journal of the American Medical Association·P Michael HoJohn S Rumsfeld
May 28, 2009·The Annals of Pharmacotherapy·Nicholas B NorgardGeoffrey C Wall
Jun 16, 2009·Cardiology in Review·Saira Chand Khalique, Angela Cheng-Lai

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