Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

Nature Communications
Mady ElbahriMoheb Abdelaziz

Abstract

The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications.

References

Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Apr 15, 2003·Virchows Archiv : an International Journal of Pathology·Bence SiposGünter Klöppel
Jun 6, 2003·Environmental Science & Technology·C C Wong, W Chu
Nov 13, 2003·Journal of the American Chemical Society·Poovathinthodiyil RaveendranScott L Wallen
Oct 10, 2006·Experimental Cell Research·Lutz ThonDieter Adam
Mar 6, 2007·Journal of Colloid and Interface Science·Tadao Sugimoto
Dec 28, 2007·Applied Physics Letters·K M ReddyAlex Punnoose
Oct 24, 2008·Advances in Colloid and Interface Science·Virender K SharmaYekaterina Lin
Aug 24, 2010·Particle and Fibre Toxicology·Syed K SohaebuddinLiping Tang
Jul 29, 2011·Nanomedicine·Bokyung KongSang Bok Lee
Feb 26, 2013·Trends in Biotechnology·Oxana V KharissovaVictor M Jiménez Pérez
Jun 14, 2013·Cellular and Molecular Life Sciences : CMLS·Justyna SosnaDieter Adam
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Avnesh S Thakor, Sanjiv S Gambhir
Oct 31, 2013·Nature Communications·Ramzy AbdelazizMady Elbahri
Nov 29, 2013·Science Translational Medicine·Eric M PridgenOmid C Farokhzad
Jan 24, 2014·Nature Reviews. Molecular Cell Biology·Tom Vanden BerghePeter Vandenabeele
Aug 8, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Valerii OrelIgor Shchepotin
Aug 27, 2014·Nature Communications·Yuanpei LiKit S Lam
May 1, 2015·Cell Communication and Signaling : CCS·Stephan PhilippDieter Adam
Mar 15, 2016·Nature Nanotechnology·Eric C Peterson, Laura E Ewing
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Stephan PhilippDieter Adam

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Citations

Mar 6, 2021·Bioactive Materials·Jin HePeng Huang
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zechun DangTongsheng Chen

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Methods Mentioned

BETA
electron diffraction
dynamic light scattering
density gradient centrifugation
flow cytometry
electrophoresis

Software Mentioned

Malvern
Malvern DTS
Rayflex

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