Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study

Medicine
Kyung-Sun NaSuk-Woo Yang

Abstract

The impact of underweight on the risk of developing primary open-angle glaucoma (POAG) is not known, although the association between obesity and POAG has been well studied. We evaluated the risk of POAG among underweight patients by studying a nationwide cohort sample in South Korea.We analyzed data from the Korean National Health Insurance Research Database collected between 2009 and 2012 for 17,000,636 patients aged 40 years or older. Newly diagnosed POAG in the cohort was identified using claims data between 2009 and 2015.A total of 442,829 individuals (2.60%) were classified as underweight (body mass index [BMI] < 18.5 kg/m). During the follow-up period, 435,756 (2.56%) subjects were newly diagnosed with POAG. Multivariate analyses revealed that underweight was significantly related to an increased risk of future POAG development, by 9.8% and 27.8% in individuals with and without diabetes, respectively. There was a reverse J-shaped relationship between BMI and risk of POAG in the normal, impaired glucose tolerance, and diabetes groups; especially, this relationship was most notable in participants with diabetes.Patients who were underweight exhibited a significantly higher prospective risk of POAG, even after adjusting for...Continue Reading

References

Jul 1, 1995·Archives of Ophthalmology·M C LeskeA P Schachat
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Aug 8, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P DeurenbergS Guricci
Feb 6, 2004·Annals of Internal Medicine·Andrea A HowardMarc N Gourevitch
Nov 25, 2004·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Dec 24, 2004·The New England Journal of Medicine·Frank B HuJoAnn E Manson
Apr 21, 2005·JAMA : the Journal of the American Medical Association·Katherine M FlegalMitchell H Gail
Jul 5, 2005·BMJ : British Medical Journal·Philip C MaierYngve T Falck-Ytter
Sep 16, 2005·The New England Journal of Medicine·Jiang HePaul K Whelton
Aug 24, 2006·The New England Journal of Medicine·Kenneth F AdamsMichael F Leitzmann
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Carole WilliJacques Cornuz
May 14, 2008·Cardiovascular Research·Morris KarmazynAsad Zeidan
Aug 13, 2008·Archives of Ophthalmology·Nishani AmerasingheUNKNOWN SiMES Study Group
Dec 17, 2008·Survey of Ophthalmology·Anne L Coleman, Stefano Miglior
Mar 13, 2009·The New England Journal of Medicine·Young H KwonWallace L M Alward
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Apr 29, 2010·Current Hypertension Reports·Stephen A MorseEfrain Reisin
Feb 9, 2011·Nutrition Journal·Kamila Jauch-CharaKerstin M Oltmanns
Feb 16, 2011·Archives of Ophthalmology·Wishal D RamdasNomdo M Jansonius
Apr 13, 2011·Ophthalmology·Paula Anne Newman-CaseyJoshua D Stein
May 20, 2014·Acta Ophthalmologica·Mijin KimDong Myung Kim
Oct 7, 2014·Ophthalmology·Di ZhaoEliseo Guallar
May 6, 2015·Annals of Internal Medicine·Pierluigi CostanzoStephen L Atkin
Aug 16, 2015·Archives of Gerontology and Geriatrics·Deepa SumukadasEmanuele Trucco
Nov 12, 2015·BioMed Research International·Seong Hee ShimKi Chul Sung
Feb 26, 2016·Diabetes & Metabolism Journal·Yong Ho LeeUNKNOWN Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association
May 2, 2016·International Journal of Cardiology·Si-Hyuck KangSeil Oh
Oct 6, 2016·American Journal of Ophthalmology·Hyun Tae KimUNKNOWN Korean Ophthalmological Society
Dec 16, 2016·Medicine·Ga Eun NamUNKNOWN and the Epidemiologic Survey Committee of the Korean Ophthalmologic Society
Jun 14, 2017·European Journal of Epidemiology·Henriët SpringelkampNomdo M Jansonius
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Yang-Hyun KimUNKNOWN Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity

❮ Previous
Next ❯

Citations

May 9, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Clarissa Ng Yin LingCharumathi Sabanayagam

❮ Previous
Next ❯

Software Mentioned

R
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.