PMID: 8590309Nov 1, 1995Paper

Undetectable interferon-alpha serum levels in a patient with atopic dermatitis

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
J G Dolen, A Mathur

Abstract

A 3-year-old boy [corrected] was evaluated for the possible diagnosis of hyperimmunoglobulin E syndrome (HIES). From the age of 4 months he developed significant atopy and was subsequently diagnosed with severe atopic dermatitis, asthma, and allergic rhinitis, with moderately high total serum IgE levels. Because IgE production has been shown to be regulated by cytokines produced by the CD4+ helper T lymphocyte subsets, we measured the circulating levels of cytokines representative of these cellular subsets in this patient. We therefore measured serum levels of interleukin-4 (IL-4), the Th2 subset-derived cytokine that upregulates IgE synthesis, as well as the levels of interferon-gamma and interferon-alpha (IFN-gamma/alpha), cytokines produced by the Th1 subset that inhibit IL-4-mediated IgE upregulation. We found that in this patient, IL-4 levels were normal, indicating normal Th2 activity. The levels of IFN-gamma were higher than normal, but the serum IFN-alpha levels in this patient were undetectable and were actually below the normal range. Thus, even though both IFN-gamma and IFN-alpha have been shown to be necessary for controlling IL-4 actions, the selective absence of IFN-alpha, even in the presence of normal or increas...Continue Reading

References

Sep 1, 1991·The Journal of Investigative Dermatology·F L van der HeijdenM L Kapsenberg
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
May 19, 1988·The New England Journal of Medicine·R S ShapiroA Filipovich

❮ Previous
Next ❯

Citations

Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Yi-Hsing ChenJohn T Schroeder
Jan 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A PrabhuA Mathur
Jul 1, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W J JabsH Kirchner
May 16, 2008·Allergologia et immunopathologia·J Torres-BorregoC Montes-Mendoza
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K MitsuishiH Ogawa
Dec 3, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B R HagmannM Fux
Apr 22, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Robert P Numerof, Khusru Asadullah
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.