PMID: 8598703Feb 10, 1996Paper

Undiagnosed systemic lupus erythematosus in the community

Lancet
A E JohnsonP A Bacon

Abstract

Systemic lupus erythematosus (SLE) produces a wide range of symptoms, some of them mild; therefore it may be underdiagnosed. In a pilot study we tested the ability of a screening questionnaire to identify undiagnosed cases in the community. A 10-item questionnaire was mailed to 3500 women aged 18-65 randomly selected from a general practice list in Birmingham, UK. A random sample of 300 non-respondents were sent two further mailings. Women returning the questionnaire with three positive answers were to attend for an antinuclear antibody (ANA) test; and those testing positive were to be referred to a rheumatologist for standard clinical assessment. 1153 (30%) of the women responded, and 307 of these gave three or more positive answers on the questionnaire. The survey disclosed three women with previously undiagnosed SLE; and, in addition, it picked up all four of the women whose SLE had been diagnosed previously. The prevalence of SLE revealed by this survey in Birmingham women is 200/100,000 (95% confidence interval 80 to 412), whereas the prevalence of diagnosed SLE in this age group is 54/100,000 (95% CI 47-62). Thus, a substantial number of undiagnosed cases exist, and further work needs to focus on the prevalence in differe...Continue Reading

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Feb 2, 2008·Arthritis Research & Therapy·Qing Yu ZengNai Zheng Zhang

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Citations

May 1, 1997·Archives of Disease in Childhood·M ShrinathA L Herrick
May 7, 2013·BMC Medicine·Natasha JordanDavid P D'Cruz
Nov 30, 2000·Arthritis Research·M Molokhia, P McKeigue
Jan 13, 2009·Seminars in Arthritis and Rheumatism·Guillermo J Pons-EstelGlinda S Cooper
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Eli GevaAmi Amit
Oct 1, 2009·Arthritis and Rheumatism·S Sam LimEmily C Somers
Jul 1, 2010·Journal of the Saudi Heart Association·Abdulrahman M Al-Moghairi
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A JordanA G Baxter
Oct 19, 2007·The Cochrane Database of Systematic Reviews·D CrosbieS Thomas

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