"Undiagnosing" multiple sclerosis: the challenge of misdiagnosis in MS.

Neurology
Andrew J SolomonDennis Bourdette

Abstract

To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). A cross-sectional Internet-based physician survey of MS specialists was performed. The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported having evaluated 1 or more patients who had been diagnosed with MS, but who they strongly felt did not have MS, within the last year. The majority of respondents (>90%) also reported the use of disease-modifying therapy in a proportion of these patients. Most respondents (94%) found clinical encounters with these patients equally or more challenging than giving a new diagnosis of MS. Fourteen percent of respondents reported that they did not always inform such patients of their opinion that they did not have MS. The misdiagnosis of MS is common and has significant consequences for patient care and health care system costs. Caring for a patient with a misdiagnosis of MS is challenging, and at times honest disclosure of a misdiagnosis represents an important ethical concern for neurologists. More data are needed on this patient population to improve diagnostic acumen and the care of these patients.

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Citations

Oct 22, 2013·Current Neurology and Neuroscience Reports·Andrew J Solomon, Brian G Weinshenker
Aug 7, 2013·Continuum : Lifelong Learning in Neurology·Andrew J Solomon, Eran Klein
Jan 1, 2012·The Primary Care Companion to CNS Disorders·Emmanuelle Waubant
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Saeed Shahbeigi, Joel Oger
Feb 24, 2016·Annals of Clinical and Translational Neurology·Andrew J SolomonDaniel S Reich
Oct 29, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·C CrespoM Brosa
Sep 18, 2015·Neurologia i neurochirurgia polska·Joanna PrzybekAnna Członkowska
Jun 27, 2015·Current Neurology and Neuroscience Reports·Michel ToledanoAndrew J Solomon
Mar 26, 2014·Practical Neurology·Jan A CoeberghColin J Mumford
Jun 5, 2016·Continuum : Lifelong Learning in Neurology·Aaron E Miller
Sep 13, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nicolae SarbuJames G Smirniotopoulos
Dec 3, 2016·Expert Review of Molecular Diagnostics·Matteo GastaldiDiego Franciotta
Jun 1, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Rotem OrbachAnat Achiron
May 22, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Wallace J Brownlee, Olga Ciccarelli
Sep 8, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Wallace J BrownleeDavid H Miller
Apr 21, 2017·Expert Review of Clinical Immunology·Thomas Berger
May 10, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Magnhild Sandberg-Wollheim, Tomas Olsson
Apr 10, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Lou Brundin
Apr 12, 2018·Expert Review of Neurotherapeutics·Crystal Dixon, Derrick Robertson
Nov 17, 2017·Neurodegenerative Disease Management·Thomas Berger
Dec 6, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Giannina ArruGian Pietro Sechi
Aug 19, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Andrew J SolomonDaniel S Reich
Apr 28, 2018·AJNR. American Journal of Neuroradiology·J-M TillemaJ D Port
Apr 17, 2013·Nature Reviews. Neurology·José C Álvarez-Cermeño, Luisa M Villar
Aug 12, 2017·Nature Reviews. Neurology·Andrew J Solomon, John R Corboy
Jun 5, 2019·Continuum : Lifelong Learning in Neurology·Andrew J Solomon
May 23, 2019·Journal of Neurology·Dennis WalzlJon Stone
Oct 23, 2018·Neurology. Neuroimmunology and Neuroinflammation·Amal P R SamaraweeraNikos Evangelou
Aug 2, 2017·Neurology. Neuroimmunology and Neuroinflammation·Andrew J SolomonDaniel S Reich
Mar 9, 2018·Neurology·Aaron E Miller, Peter A Calabresi
Apr 16, 2019·Current Opinion in Neurology·Hans-Peter HartungMichael H Barnett
Mar 13, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Andrew J SolomonBrian Weinshenker
Sep 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chen MakranzAlexander Lossos
Sep 15, 2018·AJNR. American Journal of Neuroradiology·J D DworkinR T Shinohara

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