PMID: 9541093Apr 16, 1998Paper

Undifferentiated connective tissue diseases: the clinical and serological profiles of 91 patients followed for at least 1 year

Lupus
M MoscaS Bombardieri

Abstract

The objective of this work was to evaluate the clinical and serological profiles of patients with undifferentiated connective tissue diseases (UCTD) who had been followed for at least 1 year. The retrospective analysis (197495) was based on UCTD patients diagnosed on the basis of clinical manifestations suggestive of a connective tissue disease, and the presence of at least one non-organ-specific autoantibody. A total of 91 patients were evaluated. The condition of 79 remained stable during the follow up, while in 12 the UCTD evolved to systemic lupus erythematosus (SLE) within a mean period of 3 years (min. 1 year, max. 8 years, median 2 years) after the onset of the disease. At baseline none of the variables, considered alone, showed an association with the future development of SLE. Multiple regression analysis, however, suggested that the association of sicca symptoms, Raynaud's phenomenon and/or photosensitivity was inversely correlated with the development of SLE (P = 0.0012, Fisher's exact test). The most common clinical manifestations of UCTD included arthritis, arthralgias, Raynaud's phenomenon, xerostomia, xerophthalmia and leukopenia. The stable UCTD patients showed a simple autoantibody profile characterized by a si...Continue Reading

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Citations

Dec 17, 2009·Rheumatology International·Pawan HariLuis Afonso
Apr 17, 2008·Nature Clinical Practice. Rheumatology·Marta MoscaStefano Bombardieri
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·Brent W KinderTalmadge E King
Oct 22, 2008·Arthritis Research & Therapy·Eva ZoldEdit Bodolay
May 8, 2008·World Journal of Gastroenterology : WJG·Ying ZhangBao-En Wang
Feb 13, 2014·Journal of Autoimmunity·Marta MoscaStefano Bombardieri
Sep 8, 2004·Clinical Rheumatology·Rossella De AngelisPatrizia Blasetti
Dec 2, 2014·Rheumatic Diseases Clinics of North America·Julie M Robertson, Judith A James
Oct 30, 2012·Immunology and Allergy Clinics of North America·Amy L OlsonAryeh Fischer
Aug 21, 2012·Lancet·Aryeh Fischer, Roland du Bois
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Marta MoscaStefano Bombardieri
Mar 1, 2012·Clinics in Chest Medicine·Brent Wayne Kinder
Sep 25, 2010·Autoimmunity Reviews·Marta MoscaStefano Bombardieri
Dec 11, 2007·Best Practice & Research. Clinical Rheumatology·Marta MoscaStefano Bombardieri
Jul 30, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Barry N J Walters
Dec 18, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·Z Nagy, L Czirják
Feb 6, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·E PestelliP Fabbri
Apr 13, 2004·Arthritis and Rheumatism·Pietro Enea LazzeriniFranco Laghi-Pasini
May 3, 2006·International Journal of Dermatology·Haider M Al Attia
Nov 18, 2006·Autoimmunity Reviews·M MoscaS Bombardieri
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Thomas Grader-Beck, Fredrick M Wigley
May 1, 2009·Orvosi hetilap·Edit Bodolay, Gyula Szegedi
Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·Michael Hughes, Ariane L Herrick
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Martin AringerJosef S Smolen
Jan 30, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Daniel Antunes Silva PereiraBruno Guedes Baldi
May 15, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Daniel Antunes Silva PereiraCarlos Roberto Ribeiro Carvalho

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