Undifferentiated renal cell carcinoma in infancy: report of a case and review of literature

Pediatric Pathology
Y SengaK Misugi

Abstract

A case of rapidly progressed undifferentiated renal cell carcinoma in a 2 2/12-month-old boy is reported. The histology is characterized by sarcomalike spindle and pleomorphic cells and bizarre giant cells, thus creating many difficulties in the differential diagnosis. The diagnosis of renal cell carcinoma was established on the basis of tubular formation by clear and granular cells observed in a few discrete areas. The literature on renal cell carcinoma occurring under 10 years of age was reviewed, with special attention given to histological typing. It is generally believed that renal cell carcinoma in children is well differentiated, but 2 of 39 cases reviewed were undifferentiated. We conclude that renal cell carcinoma in infants or young children may have an undifferentiated, atypical histological appearance and can progress rapidly. The differential diagnosis from anaplastic Wilms' tumor and sarcomatous tumors of the kidney in children is discussed.

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Citations

Dec 1, 1987·Acta Pathologica Japonica·I AokiS Kikyo
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Kazuaki Misugi
May 1, 1996·The Journal of Urology·A L FreedmanC A Smith
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo IndolfiM Teresa Di Tullio
Jan 1, 1991·Medical and Pediatric Oncology·I LeuschnerD Schmidt

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