Unease on the role of glyoxalase 1 in high-anxiety-related behaviour

Trends in Molecular Medicine
Paul J Thornalley

Abstract

Overexpression and silencing of glyoxalase 1 (Glo1) in brains of mice and behavioural analyses have suggested a link between Glo1 and anxiety, making Glo1 a possible novel target for anxiolytic-drug development. However, this finding is discordant with others, and further research at metabolic level, particularly glycation of neuronal proteins by dicarbonyl substrates of Glo1, is required. Therefore, it remains to be established whether Glo1 is a risk marker or a risk factor of increased anxiety, how applicable the association between Glo1 and anxiety is and whether it can be translated into clinical diagnostic and therapeutic applications.

References

Jun 1, 1986·Diabetes·G A ReichardO E Owen
Feb 15, 1993·European Journal of Biochemistry·S A Phillips, P J Thornalley
Jul 21, 1999·Biochemical Pharmacology·E A AbordoP J Thornalley
Feb 21, 2002·Vision Research·B ChangJ R Heckenlively
Jun 28, 2002·Brain Research. Brain Research Reviews·Matthias Kneussel
Jul 29, 2003·Diabetes·Roya Babaei-JadidiPaul J Thornalley
Sep 24, 2004·American Journal of Medical Genetics. Part a·Mohammed A JunaidRaju K Pullarkat
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Stamatina AgalouPaul J Thornalley
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simone A KrömerChristoph W Turck
Jul 23, 2005·Annals of the New York Academy of Sciences·Paul J Thornalley
Sep 3, 2005·Nature Reviews. Drug Discovery·John F Cryan, Andrew Holmes
Oct 26, 2005·Nature·Iiris HovattaCarrolee Barlow
Dec 8, 2005·Nature Medicine·Jay A Gingrich

❮ Previous
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Citations

Dec 25, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K Ganesh KumarBrenda K Smith Richards
May 16, 2012·The Journal of Clinical Investigation·Margaret G DistlerAbraham A Palmer
Jun 4, 2008·BMC Genomics·Victoria NembawareCathal Seoighe
Jun 7, 2008·Drug Metabolism and Drug Interactions·Bengt Mannervik
Apr 2, 2010·Oxidative Medicine and Cellular Longevity·Jaouad BouayedRachid Soulimani
Feb 23, 2008·Annals of Medicine·Iiris Hovatta, Carrolee Barlow
Jun 15, 2010·Journal of Psychiatric Research·Daniela EserRainer Rupprecht
Jan 13, 2010·Behavioural Brain Research·Samina SalimGaurav Chugh
Jul 16, 2008·Brain, Behavior, and Immunity·Hassan RammalRachid Soulimani
May 6, 2008·Neuroscience Letters·Michiko FujimotoYoshifumi Watanabe
Aug 29, 2006·Neuroscience and Biobehavioral Reviews·Rainer LandgrafElisabeth Frank
Mar 22, 2014·Biochemical Society Transactions·Alaa ShafieNaila Rabbani
May 29, 2016·Physiology & Behavior·Fernanda HansenCarlos-Alberto Gonçalves
Jun 16, 2006·Molecular & Cellular Proteomics : MCP·Claudia DitzenChristoph W Turck
Aug 16, 2018·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Alicia CarissimiGabriel N Pires
Nov 5, 2019·Neurochemistry International·Alcir Luiz DafrePamela Maher

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