Unequivocal evidence of genotoxic potential of argemone oil in mice

International Journal of Cancer. Journal International Du Cancer
Kausar M AnsariMukul Das

Abstract

Consumption of mustard oil adulterated with argemone oil leads to a clinical condition, commonly referred to as "Epidemic Dropsy." Since in vitro studies have shown that sanguinarine, an active benzophenanthridine alkaloid of argemone oil, intercalates DNA molecule, the in vivo clastogenic and DNA damaging potential of argemone oil was investigated in mice. Swiss albino mice were intraperitoneally administered 0.5, 1.0, 2.0 and 4.0 ml/kg body wt. of argemone oil to analyze chromosome aberrations and micronucleus test, while 0.25, 0.5, 1.0 and 2.0 ml/kg body wt. were given for alkaline comet assay. The frequencies of chromosomal aberrations and micronucleated erythrocytes formation in mouse bone marrow cells increased in a dose-dependent manner following argemone oil treatment. However, significant induction in chromosomal aberrations (83%) and micronucleated erythrocytes formation (261%) were observed at a minimum dose of 1.0 ml/kg. The results of comet assay revealed DNA damage in blood, bone marrow and liver cells following argemone oil treatment. Olive tail moment (OTM) and tail DNA showed significant increase in bone marrow (35-44%) and blood cells (25-40%) even at a dose of 0.25 ml/kg body wt. of argemone oil. In liver cel...Continue Reading

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Citations

Apr 23, 2008·Cell Biology and Toxicology·Alok DhawanDevendra Parmar
Jan 14, 2016·Drug and Chemical Toxicology·Ilika Ghosh, Anita Mukherjee
Oct 3, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kausar M Ansari, Mukul Das
May 20, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Challagundla K BabuMukul Das
Feb 5, 2008·Chemico-biological Interactions·Smita S MatkarUtha Hellmann-Blumberg
Jun 28, 2005·International Journal of Cancer. Journal International Du Cancer·Mukul DasSubhash K Khanna
Apr 6, 2006·Environmental and Molecular Mutagenesis·Saurabh ChandraShrawan K Gupta
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kausar M AnsariMukul Das
Mar 24, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ch Kishore BabuMukul Das
Aug 24, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ZdarilováZ Dvorák
Nov 11, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Vivek MishraMukul Das
Aug 21, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Anu PalKausar Mahmood Ansari
Jan 1, 2008·Toxicology Mechanisms and Methods·Naveen P Reddy, Mukul Das

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