Uneven changes in circulating blood cell counts with adrenergic stimulation to the canine spleen

Clinical and Experimental Pharmacology & Physiology
Yoshihiko OjiriMatao Sakanashi

Abstract

1. Responses of splenic diameter measured by sonomicrometry to alpha- and beta-adrenoceptor stimulants were estimated together with simultaneously measured systemic arterial and splenic venous concentrations of red blood cells (RBC), white blood cells (WBC) and platelets (PLT) in anaesthetized dogs. 2. Intravenous and intrasplenic arterial injections of adrenaline, noradrenaline and phenylephrine all produced profound decreases in splenic diameter. Increases in systemic arterial concentrations of RBC produced by these stimulants were observed immediately following the splenic contraction and marked increases in splenic venous concentration of RBC. 3. Adrenaline and noradrenaline both caused rapid and transient decreases in WBC release from the spleen and these agonists then, in addition to phenylephrine, caused gradual and small increases in systemic arterial WBC concentrations. The increases in arterial RBC and WBC concentrations were abolished by transient isolation of the spleen from the systemic circulation. These three agents did not significantly modify differences between splenic venous and systemic arterial concentrations of PLT. 4. Intra-arterial injections of isoprenaline caused an increase in splenic diameter and a s...Continue Reading

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Citations

Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Darija BakovićZeljko Dujić
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Katsuhiko NoguchiMatao Sakanashi
Jul 21, 2004·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·G KemmingE Thein
Aug 20, 2015·Journal of Sports Sciences·Roy J Shephard
May 7, 2014·Veterinary Clinical Pathology·R LavouéC Trumel
Jul 3, 2018·Acta Anaesthesiologica Scandinavica·Junichi Saito, Kazuyoshi Hirota
Jul 5, 2018·Acta Anaesthesiologica Scandinavica·Tor Damén, Andreas Nygren
Jul 22, 2018·The Journal of International Medical Research·Xiaoxi PangCheng'en Wang
Mar 4, 2008·The Journal of Experimental Biology·Sheva KhorramiWarren Burggren

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