PMID: 8610117Apr 2, 1996Paper

Unexpected beta2-microglobulin sequence diversity in individual rainbow trout

Proceedings of the National Academy of Sciences of the United States of America
B P ShumP Parham

Abstract

For mammals beta2-microglobulin (beta2m), the light chain of major histocompatibility complex (MHC) class I molecules, is invariant (or highly conserved) and is encoded by a single gene unlinked to the MHC. We find that beta2m of a salmonid fish, the rainbow trout (Oncorhynchus mykiss), does not conform to the mammalian paradigm. Ten of 12 randomly selected beta2m cDNA clones from an individual fish have different nucleotide sequences. A complex restriction fragment length polymorphism pattern is observed with rainbow trout, suggesting multiple beta2m genes in the genome, in excess of the two genes expected from the ancestral salmonid tetraploidy. Additional duplication and diversification of the beta2m genes might have occurred subsequently. Variation in the beta2m cDNA sequences is mainly at sites that do not perturb the structure of the mature beta2m protein, showing that the observed diversity of the trout beta2m genes is not primarily a result of pathogen selection.

References

Aug 23, 1990·Nature·B PérarnauF A Lemonnier
Aug 15, 1991·Nature·J C Howard
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P W HedrickP Parham
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Mar 1, 1995·Developmental and Comparative Immunology·B DixonR J Stet
Jan 1, 1994·Critical Reviews in Immunology·P Le Bouteiller

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Citations

Mar 7, 2006·Immunogenetics·Johannes Martinus DijkstraMitsuru Ototake
Jun 9, 2005·Fish & Shellfish Immunology·Uwe FischerTeruyuki Nakanishi
Nov 1, 1996·Developmental and Comparative Immunology·J D HansenL Du Pasquier
Jan 23, 1999·Immunological Reviews·R J StetG F Wiegertjes
Jan 23, 1999·Immunological Reviews·S Bartl
Nov 3, 2012·Developmental and Comparative Immunology·Rute D PintoNuno M S dos Santos
Apr 11, 2008·Veterinary Immunology and Immunopathology·Changxin WuBarbara Blacklaws
May 11, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Stephen C KalesBrian Dixon
Sep 29, 2004·Fish & Shellfish Immunology·Uwe FischerMitsuru Ototake
Oct 19, 2006·Fish & Shellfish Immunology·Darah ChristieBrian Dixon
Jan 16, 2003·Fish & Shellfish Immunology·Johannes Martinus DijkstraMitsuru Ototake
Jan 16, 1998·Immunity·M UhrbergP Parham
Apr 28, 2005·Developmental and Comparative Immunology·Rebecca StewartMartin D Watson
Oct 13, 2009·Veterinary Immunology and Immunopathology·Hidehiro KondoTakashi Aoki
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ShumP Parham
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiko AoyagiTeruyuki Nakanishi
Feb 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko OhtaMartin F Flajnik
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine E MagorPeter Parham

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