Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication.

PloS One
Leandro F TarossoEsper G Kallas

Abstract

HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus. Here we compared cellular immune responses against nef and vif-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides. This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.

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Citations

Oct 2, 2012·Virology Journal·Ana Carolina Soares de OliveiraSabri Saeed Sanabani
Jan 22, 2013·Viral Immunology·Jiani DuWenzheng Jiang
Jun 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Peter J KueblerEsper G Kallás
Mar 30, 2017·PloS One·Michelle ZanoniRicardo Sobhie Diaz
Jul 12, 2017·Immunogenetics·Zachary A Silver, David I Watkins
Nov 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan WuGeorge F Gao

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Methods Mentioned

BETA
ELISA
PCR
DNA assay

Software Mentioned

BIONJ
Mega
NetMHC
Sequencher
ClustalX
PHYML

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