Unexpected effects of voluntary exercise training on natriuretic peptide and receptor mRNA expression in the ob/ob mouse heart

Regulatory Peptides
Tom L BroderickJolanta Gutkowska

Abstract

Regular exercise is generally recommended for the treatment of obesity and type 2 diabetes. Exercise reduces body weight, improves glycemic control and cardiovascular (CV) function. This study was designed to determine the impact of voluntary wheel running on the cardiac oxytocin (OT)-natriuretic peptide (NP) system and plasma CV risk factors in the ob/ob mouse, a model of insulin resistance coupled with severe obesity. Five-week-old male ob/ob mice and non-obese heterozygote control littermates were assigned to either a sedentary or running group. Voluntary running was performed using a wheel system for a period of 8 weeks. Compared to non-obese mice, daily running activity expressed in kilometers, was significantly lower in ob/ob mice. In these mice, voluntary running improved body weight, but exacerbated CV markers, including plasma glucose and triglyceride levels. OT receptor gene expression was decreased in hearts of ob/ob mice compared to non-obese mice, and no improvement in the expression of this receptor was observed after voluntary running. Hearts from ob/ob mice also expressed lower BNP mRNA, whereas no differences in A- and C-type NP were observed between non-obese and ob/ob mice. After voluntary running, a downregu...Continue Reading

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Citations

Dec 6, 2014·Basic Research in Cardiology·Rita FerreiraRui Vitorino
Jun 9, 2016·BMC Endocrine Disorders·Marek JankowskiJolanta Gutkowska
Dec 18, 2019·International Journal of Molecular Sciences·Dae Yun SeoJin Han
Mar 29, 2020·Frontiers in Physiology·Gaia FaveroRita Rezzani
Jan 16, 2018·JACC. Basic to Translational Science·Maria Valero-MuñozFlora Sam

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