Unexpected eosinophilia in children affected by hydrocephalus accompanied with shunt infection

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Bartosz PolisEmilia Nowosławska

Abstract

The aim of the article is to describe an immunological reaction to shunt infection in children with hydrocephalus. The main cause of shunt infection involves methicillin resistant Staphylococcus epidermidis (Bhatia et al. Indian J Med Microbiol 35:120-123, 2017; Hayhurst et al. Childs Nerv Syst 24:557-562, 2008; Martínez-Lage et al. Childs Nerv Syst 26: 1795-1798, 2010; Simon et al. PLoS One, 2014; Snowden et al. PLoS One 8:e84089, 2013; Turgut et al. Pediatr Neurosurg 41:131-136, 2005), a bacterial strain which is responsible for the formation of biofilm on contaminated catheters (Snowden et al. PLoS One 8:e84089, 2013; Stevens et al. Br J of Neurosurg 26: 792-797, 2012). The study group involved 30 children with congenital hydrocephalus after shunt system implantation, whose procedures were complicated by S. epidermidis implant infection. Thirty children with congenital hydrocephalus awaiting their first-time shunt implantation formed the control group. The level of eosinophils in peripheral blood was assessed in both groups. Cerebrospinal fluid (CSF) was examined for protein level, pleocytosis, interleukins, CCL26/Eotaxin-3, IL-5, IL-6, CCL11/Eotaxin-1, CCL3/MIP-1a, and MBP. Three measurements were performed in the study gro...Continue Reading

References

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Oct 27, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Caroline HayhurstConor L Mallucci
Nov 6, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Scott L ParkerGeorge I Jallo
Dec 17, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Juan F Martínez-LageMaría-José Almagro
Jul 23, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R Shane TubbsAaron A Cohen-Gadol
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