Unexpected hepatitis B virus transmission after liver transplant from nucleic acid testing- and serology-negative liver donors who are hepatitis C viremic.

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Kyle R KreitmanBenedict J Maliakkal

Abstract

The opioid epidemic has led to increased availability of organs for liver transplantation. The success of direct-acting antiviral therapy for hepatitis C (HCV) has led to the acceptance of HCV viremic donor organs. Nucleic acid testing (NAT) has led to increased detection of HCV and hepatitis B (HBV) in potential donors. A total of 36 patients underwent liver transplantation from donation after brain death donors who were HCV NAT-positive, and three of them were diagnosed with HBV several months after. All three recipients received livers from HCV viremic donors who were negative for HBV by serology and NAT. Soon after liver transplantation, HCV was treated, and all achieved sustained virologic response. They became HBV DNA-positive shortly thereafter. To date, there have been no reported cases of unexpected HBV transmission since universal donor NAT was implemented in 2013. We postulate that the inhibitory effect of HCV viremia on HBV may have prolonged the "NAT window period" in these donors beyond the 20-22 days quoted for solitary HBV infection. These cases highlight the need for more intensive and prolonged screening for HBV in recipients of livers from HCV viremic donors.

References

Nov 26, 2002·Journal of Hepatology·Christian G SchüttlerStephan Schaefer
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Feb 4, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarS Fischer
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LevitskyUNKNOWN AST Infectious Diseases Community of Practice
Jul 12, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shih-Ho WangChao-Long Chen
Oct 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stevan A Gonzalez, James F Trotter
Dec 1, 2018·Transfusion·Sumathi RamachandranSusan L Stramer
Jul 16, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Miklos Z MolnarJames D Eason
Jan 4, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A KwongB L Kasiske
Mar 20, 2020·MMWR. Morbidity and Mortality Weekly Report·Nana WilsonNicole L Davis
Jun 26, 2020·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Jefferson M JonesSridhar V Basavaraju

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Citations

Dec 2, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi MatsuiYasuhito Tanaka

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