Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.

PloS One
Amy Hui-Mei LinBruce R Hamaker

Abstract

For starch digestion to glucose, two luminal α-amylases and four gut mucosal α-glucosidase subunits are employed. The aim of this research was to investigate, for the first time, direct digestion capability of individual mucosal α-glucosidases on cooked (gelatinized) starch. Gelatinized normal maize starch was digested with N- and C-terminal subunits of recombinant mammalian maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) of varying amounts and digestion periods. Without the aid of α-amylase, Ct-MGAM demonstrated an unexpected rapid and high digestion degree near 80%, while other subunits showed 20 to 30% digestion. These findings suggest that Ct-MGAM assists α-amylase in digesting starch molecules and potentially may compensate for developmental or pathological amylase deficiencies.

References

May 1, 1975·Comparative Biochemistry and Physiology. A, Comparative Physiology·N S TrackM Bokermann
Dec 1, 1979·Environmental Health Perspectives·S J Henning
Jul 1, 1992·The American Journal of Clinical Nutrition·J G Muir, K O'Dea
Jan 1, 1985·Annual Review of Physiology·S J Henning
Sep 10, 1973·Biochimica Et Biophysica Acta·A M Ugolev, P De Laey
Apr 12, 1973·Biochimica Et Biophysica Acta·K HiromiS Ono
Dec 1, 1971·The Proceedings of the Nutrition Society·H B McMichael
Sep 1, 1982·European Journal of Biochemistry·S H SørensenE M Danielsen
Jan 1, 1995·Critical Reviews in Biochemistry and Molecular Biology·E H Van BeersJ Dekker
Jan 1, 1993·Archives of Disease in Childhood·P McClean, L T Weaver
Jul 1, 1994·Biological Chemistry Hoppe-Seyler·H Heymann, S Günther
Feb 28, 1998·The Journal of Biological Chemistry·B L NicholsE Sterchi
Jan 23, 1999·Journal of Clinical Gastroenterology·P Layer, J Keller
Jan 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Buford L NicholsErwin Sterchi
Jul 1, 1965·Physiological Reviews·A M UGOLEV
Jun 23, 2007·The Journal of Nutrition·Roberto Quezada-CalvilloBuford L Nichols
Jun 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Roberto Quezada-CalvilloBuford L Nichols
Dec 25, 2007·Journal of the American Dietetic Association·Mary M MurphyAnne Birkett
Mar 22, 2008·The Journal of Nutrition·Roberto Quezada-CalvilloBuford L Nichols
Jan 1, 2006·Comprehensive Reviews in Food Science and Food Safety·M G SajilataPushpa R Kulkarni

❮ Previous
Next ❯

Citations

Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Bruce R HamakerRoberto Quezada-Calvillo
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Amy Hui-Mei LinBuford L Nichols
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sunil K SukumaranRobert F Margolskee
Jun 2, 2017·American Journal of Physical Anthropology·Catalina I Fernández, Andrea S Wiley
Mar 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsSen-Ichi Oda
Sep 19, 2012·The Journal of Biological Chemistry·Amy Hui-Mei LinBruce R Hamaker
Jul 11, 2013·Journal of Pediatric Gastroenterology and Nutrition·Maricela Diaz-SotomayorBuford L Nichols
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·D L Harmon, K C Swanson
May 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsRoberto Quezada-Calvillo
Jan 17, 2021·Animals : an Open Access Journal From MDPI·Ronald J Trotta, Kendall C Swanson
Oct 4, 2021·Comprehensive Reviews in Food Science and Food Safety·Konstantinos KorompokisJan A Delcour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.