Unexpected maintenance of hepatitis C viral diversity following liver transplantation.

Journal of Virology
Rebecca R GrayMarco Salemi

Abstract

Chronic hepatitis C virus (HCV) infection can lead to liver cirrhosis in up to 20% of individuals, often requiring liver transplantation. Although the new liver is known to be rapidly reinfected, the dynamics and source of the reinfecting virus(es) are unclear, resulting in some confusion concerning the relationship between clinical outcome and viral characteristics. To clarify the dynamics of liver reinfection, longitudinal serum viral samples from 10 transplant patients were studied. Part of the E1/E2 region was sequenced, and advanced phylogenetic analysis methods were used in a multiparameter analysis to determine the history and ancestry of reinfecting lineages. Our results demonstrated the complexity of HCV evolutionary dynamics after liver transplantation, in which a large diverse population of viruses is transmitted and maintained for months to years. As many as 30 independent lineages in a single patient were found to reinfect the new liver. Several later posttransplant lineages were more closely related to older pretransplant viruses than to viruses detected immediately after transplantation. Although our data are consistent with a number of interpretations, the persistence of high viral genetic variation over long pe...Continue Reading

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Citations

Oct 6, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ian A RoweDavid J Mutimer
Oct 4, 2013·Scientific Reports·Mattia C F ProsperiMarco Salemi
Jan 3, 2019·The Journal of Infectious Diseases·Jayna RaghwaniKatrina A Lythgoe
Aug 30, 2014·World Journal of Gastroenterology : WJG·Alberto Grassi, Giorgio Ballardini
Sep 27, 2019·Viral Immunology·Aleena HaqqiMuhammad Sohail Afzal
Aug 22, 2018·Immunological Reviews·Eva Bons, Roland R Regoes
Oct 8, 2020·Nature Reviews. Microbiology·Jennifer E JonesSeema S Lakdawala
Dec 19, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rebecca RoseOliver Laeyendecker

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