Unexpected regulation pattern of the IKKβ/NF-κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus)

Journal of Cellular Physiology
Yanhong WeiYun-Fang Gao

Abstract

As a typical hibernator, the Daurian ground squirrel (Spermophilus dauricus) spends considerable time in a state of reduced activity with prolonged fasting. Despite this, they experience little muscle atrophy and have thus become an interesting anti-disuse muscle atrophy model. The IKKβ/NF-κB signaling pathway is significant to muscle atrophy due to the protein degradation resulting from the upregulation of the E3 ubiquitin ligase MuRF1. The current study showed that the IKKβ/NF-κB signaling pathway and MuRF1 maintained relatively steady mRNA and protein expression levels, with little muscle atrophy observed in the soleus (slow-twitch, SOL) or extensor digitorum longus (fast-twitch, EDL) during hibernation (HIB); however, mRNA expression significantly increased in the SOL and EDL muscle during interbout arousal (IBA), as did the MuRF1 mRNA level in the SOL and MuRF1 protein level in the EDL. Interestingly, the expressions of p50 and MuRF1 significantly increased during HIB in the gastrocnemius (mixed muscle, GAS) and showed moderate atrophy, but dramatically decreased during IBA. Elevated IKKβ and p50 mRNA and protein expression in the cardiac muscle (CM) during HIB did not accompany increased MuRF1 expression or muscle wasting...Continue Reading

References

Nov 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F W Booth, M J Seider
Aug 1, 1992·Journal of Applied Physiology·Y OhiraV R Edgerton
Jan 1, 1990·Journal of Applied Physiology·D B Thomason, F W Booth
Apr 1, 1980·Biochemical Society Transactions·K Snell
Sep 1, 1995·Respiration Physiology·W D ReidW K Milsom
Aug 23, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·R T Jagoe, A L Goldberg
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·M D GomesA L Goldberg
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Bridge HunterSusan C Kandarian
Jul 18, 2002·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·F van Breukelen, S L Martin
Aug 21, 2003·Trends in Molecular Medicine·David J Glass
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
Nov 6, 2003·Journal of Applied Physiology·Gregory R AdamsKenneth M Baldwin
Dec 10, 2003·The Journal of Cell Biology·Ebru ErbayJie Chen
Apr 22, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jennifer M SacheckAlfred L Goldberg
Sep 28, 2004·Physiological and Biochemical Zoology : PBZ·Bryan C RourkeVincent J Caiozzo
Oct 14, 2004·Cell·Dongsheng CaiSteven E Shoelson
Oct 27, 2004·American Journal of Physical Medicine & Rehabilitation·Takahiro SasaNatsuo Yasui
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Brian J KrawiecCharles H Lang
Feb 16, 2006·Journal of Muscle Research and Cell Motility·Carol C GregorioAbigail S McElhinny
Feb 18, 2006·Biochemical and Biophysical Research Communications·Peter RazeghiHeinrich Taegtmeyer
Aug 25, 2006·American Journal of Physiology. Cell Physiology·Andrew R JudgeSusan C Kandarian
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M SacheckAlfred L Goldberg
Dec 13, 2006·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Chantal GuillotMonique Badier
Mar 23, 2007·Medical Hypotheses·Peng ZhangMing Fan
Mar 29, 2007·Physiological and Biochemical Zoology : PBZ·T D LohuisP A Iaizzo
Oct 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Darin Van GammerenSusan C Kandarian
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hyung ChoiBryan C Rourke
Apr 16, 2010·Physiological Reviews·Nadine Bakkar, Denis C Guttridge
Aug 13, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Megan M NowellBryan C Rourke
Jan 25, 2011·Biochemical and Biophysical Research Communications·S A ReedA R Judge
Jul 14, 2011·Aviation, Space, and Environmental Medicine·Fangying DuNandu Goswami
Jul 30, 2011·Skeletal Muscle·Stefano Schiaffino, Cristina Mammucari

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Citations

Jul 25, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hui ChangYun-Fang Gao
Feb 9, 2021·Frontiers in Physiology·Sylvain GiroudKenneth B Storey
Mar 9, 2021·Frontiers in Physiology·Fabrice BertileSylvain Giroud

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