Unexpected role of linker position on ammonium gemini surfactant lyotropic gyroid phase stability

Soft Matter
Gregory P Sorenson, Mahesh K Mahanthappa

Abstract

Arising from the water-driven self-assembly of amphiphiles over generally narrow temperature and composition phase windows, aqueous lyotropic liquid crystal (LLC) network phases are useful in applications as therapeutic delivery vehicles and templates for mesoporous material syntheses. While a clear set of amphiphile design rules that enables access to these intricate three-dimensional structures has yet to emerge, recent work indicates that bis(ammonium), bis(phosphonium), and dicarboxylate gemini ("twin tail") surfactants enable enhanced access to LLC network phases such as the double gyroid (G). In order to better understand the scope of this amphiphile design strategy, we investigated the synthesis and aqueous LLC self-assembly behaviors of a homologous series of quaternary gemini bis(ammonium) dichloride surfactants, in which we varied the position of the hydrophobic linker that connects the constituent single tail surfactants. These experiments demonstrate that the position of the linker directly impacts the maximum counterion-headgroup hydration capacity and the extent of counterion-headgroup association, all of which contribute to the aqueous lyotropic double gyroid network phase stability. Thus, judicious selection of ...Continue Reading

References

Mar 6, 2003·Journal of the American Chemical Society·Brad A PindzolaDouglas L Gin
Dec 15, 2005·Angewandte Chemie·Takashi KatoKenji Kishimoto
Nov 20, 2008·Chemistry : a European Journal·Chuanbo GaoShunai Che
Oct 30, 2010·Journal of the American Chemical Society·Cecília LealCyrus R Safinya
May 26, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Leila MivehiKrister Holmberg
Jul 22, 2011·Current Opinion in Structural Biology·Vadim Cherezov
Sep 6, 2011·Journal of the American Chemical Society·Gregory P SorensonMahesh K Mahanthappa
Jul 20, 2012·Nature·Changhong XiaoOsamu Terasaki
Sep 13, 2012·The Journal of Physical Chemistry. B·Jagannath MondalArun Yethiraj
Oct 20, 2012·Chemical Society Reviews·Lu Han, Shunai Che
Aug 12, 2015·The Journal of Physical Chemistry Letters·Dominic V PerroniMahesh K Mahanthappa

❮ Previous
Next ❯

Citations

Jan 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kyungtae KimFrank S Bates
Feb 6, 2018·The Journal of Physical Chemistry. B·Sriteja ManthaArun Yethiraj
Feb 6, 2020·Journal of the American Chemical Society·Silvio PoppeCarsten Tschierske

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.