PMID: 3153337Oct 1, 1987

Unexpected seizures during hemodialysis. Effect of dialysate prescription

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D M FordG M Lum


To assess the effects of the dialysate prescription on the intradialytic neurological stability of children requiring chronic hemodialysis (HD), continuous EEG monitoring (CEM) was performed on five children before, during and after HD against: (1) low sodium acetate (LAc: Na 132 mEq/l, acetate 38 mEq/l); (2) high sodium acetate (HAc: Na 144 mEq/l, acetate 41 mEq/l), and (3) low sodium bicarbonate (LBi: Na 133 mEq/l, bicarbonate 35 mEq/l) dialysate. Three children, two with clinically well-controlled seizure disorders and one with no seizure history, exhibited subclinical seizures on LAc and HAc but improved neurological stability on LBi. Two children had essentially unchanged CEM studies on any HD regimen. Symptoms of disequilibrium were noted in four of the five children on LAc, two of the five on HAc and only one of the five on LBi. The data suggest that bicarbonate HD may enhance intradialytic neurological stability, particularly in children with known seizure disorders. Furthermore, CEM was found to be a useful tool for evaluating the neurological stability of children during HD.


Jun 1, 1978·The Journal of Clinical Investigation·J D CooperA I Arieff
Sep 1, 1985·Kidney International·R M HakimM N Gottlieb
Jan 1, 1985·Nephron·A V CybulskyD J Hollomby
Oct 1, 1966·Archives of Internal Medicine·C L HampersJ P Merrill
Nov 1, 1982·Artificial Organs·H HamplM Kessel
May 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H W SchnaperA M Robson
Apr 26, 1984·The New England Journal of Medicine·A C Alfrey
Mar 1, 1982·Kidney International·A RotundoA F Michael
Jan 1, 1980·Nephron·A B Rivera-VázquezM Martinez-Maldonado


Jan 1, 1992·Pediatric Hematology and Oncology·J Goldman, W A McGuire

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