Unexpected Variation in Neuroanatomy among Diverse Nematode Species

Frontiers in Neuroanatomy
Ziduan HanNathan E Schroeder

Abstract

Nematodes are considered excellent models for understanding fundamental aspects of neuron function. However, nematodes are less frequently used as models for examining the evolution of nervous systems. While the habitats and behaviors of nematodes are diverse, the neuroanatomy of nematodes is often considered highly conserved. A small number of nematode species greatly influences our understanding of nematode neurobiology. The free-living species Caenorhabditis elegans and, to a lesser extent, the mammalian gastrointestinal parasite Ascaris suum are, historically, the primary sources of knowledge regarding nematode neurobiology. Despite differences in size and habitat, C. elegans and A. suum share a surprisingly similar neuroanatomy. Here, we examined species across several clades in the phylum Nematoda and show that there is a surprising degree of neuroanatomical variation both within and among nematode clades when compared to C. elegans and Ascaris. We found variation in the numbers of neurons in the ventral nerve cord and dye-filling pattern of sensory neurons. For example, we found that Pristionchus pacificus, a bacterial feeding species used for comparative developmental research had 20% fewer ventral cord neurons compared...Continue Reading

References

Aug 10, 1976·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J E Sulston
Aug 10, 1976·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A O StrettonI S Kass
Dec 1, 1977·Perceptual and Motor Skills·J Gould
Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Jul 11, 1977·Biochemical and Biophysical Research Communications·K T Yu, M K Gould
Sep 1, 1976·Journal of Ultrastructure Research·W P Wergin, B Y Endo
Aug 1, 1976·International Journal for Parasitology·T P Bonner, M Buratt
Oct 1, 1986·Developmental Biology·L A PerkinsJ G Culotti
Jun 15, 1989·The Journal of Comparative Neurology·J D AngstadtA O Stretton
Mar 1, 1974·Comparative and General Pharmacology·R Pertel, S H Wilson
Apr 1, 1968·Experimental Cell Research·O L GamborgK Ojima
Oct 26, 1984·Science·V Ambros, H R Horvitz
Oct 1, 1983·The Journal of Comparative Neurology·P S Albert, D L Riddle
Jul 22, 1993·Nature·S L McIntireH R Horvitz
Aug 24, 1999·Veterinary Parasitology·F T AshtonG A Schad
Apr 25, 2000·Developmental Biology·M A FélixP W Sternberg
Jul 13, 2000·Current Opinion in Genetics & Development·R J Sommer
May 15, 2001·American Journal of Physiology. Cell Physiology·J S DuerrJ B Rand
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E L PeckolC I Bargmann
Jan 1, 1996·Annual Review of Phytopathology·R N Perry
May 1, 1996·Parasitology Today·F T Ashton, G A Schad
May 3, 2006·The Journal of Experimental Biology·Jing-Tzyh Alan ChiangLeon Avery
Apr 17, 2007·The Journal of Comparative Neurology·Curtis M Loer, Laura Rivard
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Ralf J Sommer
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Makedonka Mitreva, Douglas P Jasmer
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Theresa Stiernagle
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·John K Yochem
Jun 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elissa A Hallem, Paul W Sternberg
Dec 17, 2008·BMC Biology·Jagan SrinivasanPaul W Sternberg
Oct 14, 2009·The Journal of Comparative Neurology·Erik J RagsdaleJames G Baldwin
Feb 13, 2010·Journal of Neuroscience Methods·Yong-Guang Tong, Thomas R Bürglin
Nov 12, 1986·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner
Aug 13, 2013·Current Biology : CB·Nathan E SchroederMaureen M Barr

❮ Previous
Next ❯

Citations

May 26, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Rebecca J AndrowskiNathan E Schroeder
Apr 12, 2017·Phytopathology·Ziduan HanNathan E Schroeder
Nov 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·James Siho LeePaul W Sternberg
Jul 1, 2020·Journal of Neurogenetics·Antoine Barrière, Vincent Bertrand
Mar 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Tess Renahan, Ralf J Sommer
Jul 28, 2016·International Journal for Parasitology·Louise E AtkinsonAngela Mousley

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
fluorescence microscopy
light microcopy
light microscopy
imaging techniques

Software Mentioned

Zen

Related Concepts

Related Feeds

Ascariasis (ASM)

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Ascariasis

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Related Papers

WormBook : the Online Review of C. Elegans Biology
R J Sommer
WormBook : the Online Review of C. Elegans Biology
R J Sommer
Current Biology : CB
Elissa A HallemPaul W Sternberg
© 2022 Meta ULC. All rights reserved