Unexpectedly long half-life of metformin elimination in cases of metformin accumulation

Diabetic Medicine : a Journal of the British Diabetic Association
Farshad KajbafJ D Lalau

Abstract

In a study of the oral administration of a single dose of metformin to healthy participants, the estimated half-life (t½ ) for the elimination of the drug from erythrocytes was found to be 23.4 h (compared with 2.7 h for metformin in plasma). However, these pharmacokinetic indices have not been well defined in metformin accumulation. We systematically reviewed all the data on plasma and erythrocyte metformin assays available in our centre. We then selected patients with a plasma metformin concentration ≥ 5 mg/l and in whom the metformin concentration had been remeasured once or more at least 5 days after admission. Twelve patients met the aforementioned criteria. All but one of these patients displayed generally severe lactic acidosis on admission (mean ± sd pH and lactate: 6.88 ± 0.35 and 14.8 ± 6.56 mmol/l, respectively) and 11 were treated with dialysis. The mean ± sd time interval between the first and last blood sample collections for metformin measurement was 8.3 ± 3.2 days (range 5-14 days). Five days after the first sample had been collected, metformin was still detectable in plasma and in erythrocytes in all patients. Metformin remained detectable for up to 13 days (both in plasma and in erythrocytes). The estimated me...Continue Reading

References

Jan 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Wilcock, C J Bailey
Mar 13, 2003·Diabetes, Obesity & Metabolism·J-D Lalau, C Lacroix
Aug 13, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Daniel Lalau
Jan 19, 2011·Clinical Pharmacokinetics·Garry G GrahamKenneth M Williams
Dec 18, 2013·Current Drug Metabolism·Suning ChenAidong Wen
Mar 15, 2014·Pharmacogenomics·Jennifer N Todd, Jose C Florez
Jul 26, 2014·Diabetes·Aaron C PawlykJose C Florez

❮ Previous
Next ❯

Citations

Oct 27, 2016·Journal of Nephrology·Alessandra MoioliPaolo Menè
Jan 17, 2016·Metabolism: Clinical and Experimental·Ralph DeFronzoThomas A Bicsak
Feb 16, 2017·The Journal of Antibiotics·Fumiaki TabuchiKazuhisa Sekimizu
Apr 19, 2017·Diabetes, Obesity & Metabolism·Jean-Daniel LalauNicolas Wiernsperger
Dec 12, 2017·Clinical Case Reports·Nicole BarrellaStephanie Nicole Simpson
Jul 9, 2017·Neurochemical Research·Eva-Maria Blumrich, Ralf Dringen
Aug 14, 2020·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Stephen A HardingMary Ann Howland
Aug 23, 2020·International Journal of Molecular Sciences·Angela DziedzicMichal Bijak
Dec 23, 2019·Journal of Pharmacokinetics and Pharmacodynamics·Carl A WesolowskiJane Alcorn
Aug 3, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Isabelle H S KuanDaniel F B Wright
Dec 30, 2020·Journal of Nephrology·Filippo Mariano, Luigi Biancone
Nov 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Edyta SutkowskaMariusz G Fleszar
Mar 19, 2021·Critical Care Medicine·Youssef BennisJean-Daniel Lalau
Jul 3, 2021·Pharmaceuticals·Yoo-Seong Jeong, William J Jusko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.