Unexplained elevated serum pancreatic enzymes: a reason to suspect celiac disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Antonio CarroccioGiuseppe Iacono

Abstract

The frequency of elevated serum pancreatic enzymes in patients with celiac disease (CD) is unknown. The aim of this study was to evaluate the serum levels of pancreatic enzymes in CD patients. Serum pancreatic isoamylase and lipase levels were assayed in 90 adult and 112 pediatric consecutive CD patients at diagnosis and after 12 months of gluten-free diet (GFD). Serum elastase and trypsin levels were assayed in a subgroup of adult CD patients. Pancreatic ultrasonography was also performed. Twenty-six adult (29%) and 29 pediatric (26%) CD patients exhibited elevated values of serum pancreatic amylase and/or lipase; trypsin was elevated in 69% and elastase in 19%. The frequency of elevated serum pancreatic enzymes observed was identical in the patients with "typical" and "atypical" CD symptoms and in the asymptomatic patients. Most of the elevated values were lower than 2-fold the threshold limits. Elevated pancreatic enzymes were not associated with alcohol consumption, drug use, presence of abdominal pain, or diabetes mellitus. Abdominal ultrasound scan showed no abnormal findings in the pancreatic region in any of the CD patients. After 12 months of GFD, pancreatic amylase was elevated in 3 cases and lipase in 2 cases; these ...Continue Reading

Citations

Jun 4, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ahmer M HameedHenry C Pleass
Aug 19, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jonas F LudvigssonAnders Ekbom
Jun 5, 2007·Best Practice & Research. Clinical Gastroenterology·Jutta KellerPeter Layer
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Aug 19, 2020·Digestive Diseases and Sciences·Motasem AlkhayyatPrabhleen Chahal
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Aug 29, 2018·Nutrients·Giulia De MarchiRachele Ciccocioppo
Aug 19, 2021·Revista da Associação Médica Brasileira·Jonathan SolderaKarla Lais Pêgas

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