Unexplained Variance in Hydration Study

Nutrients
Colleen X Muñoz, Michael Wininger

Abstract

With the collection of water-intake data, the National Health and Nutrition Examination Survey (NHANES) is becoming an increasingly popular resource for large-scale inquiry into human hydration. However, are we leveraging this resource properly? We sought to identify the opportunities and limitations inherent in hydration-related inquiry within a commonly studied database of hydration and nutrition. We also sought to critically review models published from this dataset. We reproduced two models published from the NHANES dataset, assessing the goodness of fit through conventional means (proportion of variance, R2). We also assessed model sensitivity to parameter configuration. Models published from the NHANES dataset typically yielded a very low goodness of fit R2 < 0.15. A reconfiguration of variables did not substantially improve model fit, and the goodness of fit of models published from the NHANES dataset may be low. Database-driven inquiry into human hydration requires the complete reporting of model diagnostics in order to fully contextualize findings. There are several emergent opportunities to potentially increase the proportion of explained variance in the NHANES dataset, including novel biomarkers, capturing situationa...Continue Reading

References

Jan 1, 1966·Annual Review of Physiology·G P MooreJ P Segundo
Jun 9, 2001·Journal of Public Health Dentistry·K E HellerS A Eklund
Apr 30, 2002·American Journal of Epidemiology·Jacqueline ChanGary E Fraser
Jul 1, 1962·Archives of Internal Medicine·M H JACOBSONO W DONNELLY
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brice M Stone, Cecil R Reynolds
Nov 5, 2005·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Nov 15, 2005·International Journal of Cancer. Journal International Du Cancer·Cristina M VillanuevaManolis Kogevinas
Jul 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Gabor SzinnaiMirjam Christ-Crain
Oct 27, 2007·Journal of the American College of Nutrition·Lawrence E Armstrong
Nov 23, 2007·Journal of the American Society of Nephrology : JASN·Xiaofang WangVicente E Torres
Dec 20, 2007·Psychonomic Bulletin & Review·Eric-Jan Wagenmakers
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Xuejuan JiangManuela Gago-Dominguez
May 16, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Vicente E TorresJared J Grantham
May 5, 2010·Circulation·Sofia EnhörningOlle Melander
May 19, 2010·International Journal of Sport Nutrition and Exercise Metabolism·Lawrence E ArmstrongCarl M Maresh
Jul 16, 2010·The American Journal of Clinical Nutrition·Samuel N CheuvrontMichael N Sawka
Feb 24, 2011·Nephrology·Giovanni F M StrippoliPaul Mitchell
Apr 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Sofia EnhörningOlle Melander
May 17, 2011·Journal of Sports Sciences·Oliver J PeacockDylan Thompson
Oct 14, 2011·Diabetes Care·Ronan RousselUNKNOWN D.E.S.I.R. Study Group
May 23, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S EnhörningO Melander
Aug 15, 2012·Journal of the Academy of Nutrition and Dietetics·Lawrence E ArmstrongCarl M Maresh
Sep 1, 2012·The British Journal of Nutrition·Erica PerrierIvan Tack
Jan 25, 2013·The American Journal of Clinical Nutrition·Samuel N CheuvrontMichael N Sawka
Mar 26, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·O MalisovaM Kapsokefalou
Apr 23, 2013·European Journal of Applied Physiology·Erica PerrierAlexis Klein
Apr 25, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rosemary L SchleicherChristine M Pfeiffer
May 23, 2013·European Journal of Clinical Nutrition·E PerrierA Klein
Oct 8, 2013·Environmental Health : a Global Access Science Source·Zhichao SunBhramar Mukherjee
Oct 17, 2013·European Journal of Clinical Nutrition·C X MuñozL E Armstrong
Apr 15, 2014·PloS One·Nathalie ProssIsabelle Guelinckx
Nov 12, 2014·International Journal of Sport Nutrition and Exercise Metabolism·Samuel N CheuvrontEdward J Zambraski
Jan 8, 2015·European Journal of Applied Physiology·Evan C JohnsonLawrence E Armstrong
Mar 31, 2015·American Heart Journal·Sofia EnhörningOlle Melander
Apr 14, 2015·Disease Markers·Erica T PerrierAlexis Klein
May 13, 2015·Appetite·Colleen X MuñozLawrence E Armstrong
Jul 15, 2015·The Journal of Clinical Endocrinology and Metabolism·S Goya WannametheeNaveed Sattar
Jul 24, 2015·The American Journal of Clinical Nutrition·Lawrence E Barker, Kate M Shaw
May 11, 2016·American Journal of Nephrology·William F ClarkLise Bankir
Jun 15, 2016·Annals of Nutrition & Metabolism·Olle Melander

❮ Previous
Next ❯

Citations

Mar 12, 2020·Nutrients·Evan C Johnson, William M Adams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.