Unicentric Castleman's Disease with an Unusual Clinical Behavior

Curēus
Sawsan A AljubranRizam A Alghamdi

Abstract

Castleman's disease is a rare clinicopathological condition characterized by hyperplasia of lymph nodes. We report the case of a 12-year-old boy who presented with painful oral and genital ulcers, who was assumed to have Behçet's disease. However, the patient did not show any clinical improvement on colchicine and systemic corticosteroids. Later, the patient developed severe abdominal pain and vomiting. Abdominal CT revealed a mass lesion superior to the right kidney. After a thorough investigation, he was diagnosed with unicentric Castleman's disease. Despite the complete resection of the mass, the patient continued to have the symptoms of abdominal pain and orogenital ulcers. Immunomodulatory therapy resulted in remarkable clinical improvement. This case report demonstrates how unicentric Castleman's disease can share similar clinical behavior to the multicentric disease.

References

Sep 16, 2010·Urology Annals·Sanish ShringarpureAshok Parmeswaran
Jun 18, 2011·American Journal of Hematology·Angela Dispenzieri
Jul 14, 2012·American Journal of Hematology·Angela DispenzieriThomas M Habermann
Jul 19, 2014·Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology·Feryal KaracaSemra Paydaş

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Methods Mentioned

BETA
surgical resection
biopsy

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Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

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