PMID: 7083725Jul 1, 1982Paper

Unidirectional absorption of gentamicin from the peritoneum during continuous ambulatory peritoneal dialysis

Clinical Pharmacology and Therapeutics
P SomaniJ T Higgins

Abstract

Gentamicin kinetics were determined after intravenous or intraperitoneal injection in five patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Our objective was to determine rate of absorption of gentamicin from the peritoneum into the systemic circulation and vice versa. After intraperitoneal instillation of 1 mg/kg in the CAPD fluid during a 6-hr dwell time, the antibiotic appeared in the serum within 15 min in four of five patients. Peak serum concentrations ranged between 1.6 and 7.2 mg/l(mean +/- SD = 3.52 +/- 2.22) in all five patients and the time to reach peak concentration was 3.8 +/- 1.5 hr. Peritoneal gentamicin clearance was 13 ml/min. Percent extraction of gentamicin from the PD fluid within the 6 hr of intraperitoneal exposure ranged from 65% to 100% (mean +/- SD = 86.8 +/- 13.2). The fraction of the intraperitoneal dose absorbed into systemic circulation was found to be 0.84 independently by calculating the ratio of AUCip and AUCiv. When the same dose of gentamicin was injected intravenously (1 mg/kg), no gentamicin could be detected in the peritoneal fluid in three of five patients and only a very small amount of the drug was present for a brief period of time in the remaining two. The kinetic ...Continue Reading

Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·G L TrainaM Bonati
Dec 14, 1984·Pharmaceutisch Weekblad. Scientific Edition·R Janknegt, C H Koks
Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T B GilbertA A Quaddoura
Jun 1, 1997·The Annals of Pharmacotherapy·D F Brophy, B A Mueller
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R S Trompeter
Apr 1, 1984·Infection Control : IC·S M Norris, J I Ravdin
Jan 1, 1986·European Journal of Clinical Pharmacology·D A SicaJ Baggett
Jun 16, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Julie M VargheseDwarakanathan Ranganathan
Apr 24, 1987·Pharmaceutisch Weekblad. Scientific Edition·R Janknegt, J H Koelman

Related Concepts

Gentacycol
Injections, Intraperitoneal
Intravenous Injections
Peritoneal Dialysis
Peritoneal Dialysis, Continuous Ambulatory
Secondary Peritonitis

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